Effects of Single Vitamin D₃ Injection (200,000 Units) on Serum Fibroblast Growth Factor 23 and Sclerostin Levels in Subjects with Vitamin D Deficiency.

Journal: Endocrinology and metabolism (Seoul, Korea)
Published Date: Dec 1, 2017

Abstract

BACKGROUND: Vitamin D deficiency remains common in all age groups and affects skeletal and non-skeletal health. Fibroblast growth factor 23 is a bone-derived hormone that regulates phosphate and 1,25-dihydroxyvitamin D homeostasis as a counter regulatory factor. 1,25-Dihydroxyvitamin D stimulates fibroblast growth factor 23 synthesis in bone, while fibroblast growth factor 23 suppresses 1,25-dihydroxyvitamin D production in the kidney. The aim of this study was to evaluate the effects of vitamin D₃ intramuscular injection therapy on serum fibroblast growth factor 23 concentrations, and several other parameters associated with bone metabolism such as sclerostin, dickkopf-1, and parathyroid hormone.

Authors

  • Dongdong Zhang
    Brain Korea 21 PLUS Project for Medical Science, Yonsei University, Seoul, Korea.
  • Da Hea Seo
    Division of Endocrinology and Endocrine Research Institute, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
  • Han Seok Choi
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Korea.
  • Hye Sun Park
    Division of Endocrinology and Endocrine Research Institute, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
  • Yoon Sok Chung
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Ajou University School of Medicine, Suwon, Korea.
  • Sung Kil Lim
    Brain Korea 21 PLUS Project for Medical Science, Yonsei University, Seoul, Korea.

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