Efficacy and safety of praziquantel against in the Ikata-Likoko area of southwest Cameroon.

Journal: Tropical medicine and health
Published Date: Dec 18, 2017

Abstract

BACKGROUND: Schistosomiasis remains a parasitic infection of public health importance especially in Africa south of the Sahara including Cameroon. Chemotherapy using praziquantel has been the most effective and widespread control measure used. However, there are reports of reduced efficacy of the drug. The aim of this study was to assess the efficacy and safety of praziquantel against among infected individuals in the Ikata-Likoko area of southwest Cameroon. Following a baseline study, egg load was determined using the urine filtration technique and microscopy. Participants were treated with a unique dose of praziquantel of 40 mg/Kg body weight. A control test was carried out on the 42nd day post-treatment to determine the proportion of positive participants with viable eggs (cure rate) and the egg loads. The egg loads obtained during the control and at baseline were used to calculate the egg reduction rate (ERR) used as the main indicator of praziquantel efficacy according to the WHO, 2013 protocol.

Authors

  • Calvin Bisong Ebai
    Department of Zoology and Animal Physiology, Faculty of Science, University of Buea, P.O. Box 63, Buea, SWR Cameroon.
  • Helen Kuokuo Kimbi
    Department of Zoology and Animal Physiology, Faculty of Science, University of Buea, P.O. Box 63, Buea, SWR Cameroon.
  • Irene Ule Ngole Sumbele
    Department of Zoology and Animal Physiology, Faculty of Science, University of Buea, P.O. Box 63, Buea, SWR Cameroon.
  • Jude Ebah Yunga
    Department of Zoology and Animal Physiology, Faculty of Science, University of Buea, P.O. Box 63, Buea, SWR Cameroon.
  • Leopold Gustave Lehman
    Department of Animal Biology, Faculty of Science, University of Douala, P.O. Box 24157, Douala, Cameroon.

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