Comparative molecular docking studies of lupeol and lupenone isolated from Pueraria lobata that inhibits BACE1: Probable remedies for Alzheimer's disease.

Journal: Asian Pacific journal of tropical medicine
Published Date: Oct 28, 2017

Abstract

OBJECTIVE: To discover lead lupane triterpenoid's potential isolated from Pueraria lobata roots against β-site amyloid precursor protein cleaving enzyme 1 (BACE1), which serve as a rate limiting step in amyloid beta (Aβ) production altering the course of Alzheimer's disease. In addition, enzyme kinetics study and molecular docking were conducted to establish the inhibition type and structure activity relationship.

Authors

  • Prashamsa Koirala
    Department of Food and Life Science, Pukyong National University, Busan 48513, Republic of Korea.
  • Su Hui Seong
    Department of Food and Life Science Pukyong National University Busan Korea.
  • Hyun Ah Jung
    Department of Food Science and Human Nutrition Chonbuk National University Jeonju Korea.
  • Jae Sue Choi
    Department of Food and Life Science Pukyong National University Busan Korea.

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