Insulin Resistance, Hyperinsulinemia, and Mitochondria Dysfunction in Nonobese Girls With Polycystic Ovarian Syndrome.

Journal: Journal of the Endocrine Society
Published Date: Jun 1, 2017

Abstract

OBJECTIVE: Obese girls with polycystic ovarian syndrome (PCOS) have decreased insulin sensitivity (IS), muscle mitochondrial dysfunction and increased liver fat, which may contribute to their increased risk for type 2 diabetes. Less is known regarding normal-weight girls with PCOS.

Authors

  • Melanie Cree-Green
    Division of Pediatric Endocrinology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045.
  • Haseeb Rahat
    Division of Pediatric Endocrinology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045.
  • Bradley R Newcomer
    Deptartment of Physics, James Madison University, Harrisburg, Virginia 22807.
  • Bryan C Bergman
    Division of Endocrinology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045.
  • Mark S Brown
    Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045.
  • Gregory V Coe
    Division of Pediatric Endocrinology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045.
  • Lindsey Newnes
    Division of Pediatric Endocrinology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045.
  • Yesenia Garcia-Reyes
    Division of Pediatric Endocrinology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045.
  • Samantha Bacon
    Division of Endocrinology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045.
  • Jessica E Thurston
    Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora, Colorado 80045.
  • Laura Pyle
    Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora, Colorado 80045.
  • Ann Scherzinger
    Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045.
  • Kristen J Nadeau
    Division of Pediatric Endocrinology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045.

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