Altered Pituitary Gland Structure and Function in Posttraumatic Stress Disorder.

Journal: Journal of the Endocrine Society
Published Date: Apr 13, 2017

Abstract

OBJECTIVES: Posttraumatic stress disorder (PTSD) is associated with hypothalamus-pituitary-adrenal (HPA) axis response to stressors, but links to neurophysiological and neuroanatomical changes are unclear. The purpose of this study was to determine whether stress-induced cortisol alters negative feedback on pituitary corticotroph function and pituitary volume.

Authors

  • Odelia Cooper
    Pituitary Center, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California 90048.
  • Vivien Bonert
    Pituitary Center, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California 90048.
  • Franklin Moser
    Department of Imaging, Cedars-Sinai Medical Center, Los Angeles, California 90048.
  • James Mirocha
    Biostatistics Core, Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048.
  • Shlomo Melmed
    Pituitary Center, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California 90048.

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