Hypothalamic-Pituitary-Ovarian Axis Reactivation by Kisspeptin-10 in Hyperprolactinemic Women With Chronic Amenorrhea.

Journal: Journal of the Endocrine Society
Published Date: Oct 16, 2017

Abstract

CONTEXT: Hyperprolactinemia-induced hypogonadotropic amenorrhea (hPRL-HA) is a major cause of hypothalamic gonadotrophin-releasing hormone (GnRH) deficiency in women. In hyperprolactinemic mice, we previously demonstrated that hypothalamic kisspeptin (Kp) expression was diminished and that Kp administration restored hypothalamic GnRH release, gonadotropin secretion, and ovarian cyclicity, suggesting that Kp neurons could also play a role in hPRL-HA.

Authors

  • Robert P Millar
    Centre for Neuroendocrinology, Departments of Immunology and Physiology, Faculty of Health Sciences, University of Pretoria, Pretoria 0084, South Africa.
  • Charlotte Sonigo
    INSERM U1185, Paris Sud Medical School, Le Kremlin-Bicêtre, F-94276, France.
  • Richard A Anderson
    MRC Centre for Reproductive Health, Queens Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom.
  • Jyothis George
    MRC Centre for Reproductive Health, Queens Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom.
  • Luigi Maione
    Reproductive Endocrinology Department, Le Kremlin-Bicêtre, F-94275, France.
  • Sylvie Brailly-Tabard
    Reproductive Endocrinology Department, Le Kremlin-Bicêtre, F-94275, France.
  • Philippe Chanson
    Reproductive Endocrinology Department, Le Kremlin-Bicêtre, F-94275, France.
  • Nadine Binart
    Unité INSERM 1185, Faculté de Médecine Paris Sud, Université Paris-Saclay, le Kremlin-Bicêtre, France.
  • Jacques Young
    Unité INSERM 1185, Faculté de Médecine Paris Sud, Université Paris-Saclay, le Kremlin-Bicêtre, France.

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