Hyperinsulinemia and Insulin Receptor Gene Mutation in Nonobese Healthy Subjects in Japan.

Journal: Journal of the Endocrine Society
Published Date: Oct 12, 2017

Abstract

CONTEXT: Hyperinsulinemia is often observed in obese people, owing to their insulin resistance accompanied by visceral fat accumulation, but the frequency of hyperinsulinemia in nonobese people is not well known. Mutations in the insulin receptor gene are known to cause insulin resistance and hyperinsulinemia in type A insulin resistance syndrome, Rabson-Mendenhall syndrome, and Donohue syndrome. However, insulin receptor gene abnormalities have not been investigated in asymptomatic hyperinsulinemic subjects.

Authors

  • Shingo Fujita
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, 565-0871, Japan.
  • Yohei Kuroda
    Department of Endocrinology and Metabolism, Sumitomo Hospital, Osaka, 530-0005, Japan.
  • Kenji Fukui
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, 565-0871, Japan.
  • Ryuya Iwamoto
    Department of Endocrinology and Metabolism, Sumitomo Hospital, Osaka, 530-0005, Japan.
  • Junji Kozawa
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, 565-0871, Japan.
  • Takehiko Watanabe
    Physical Check-up Center, Sumitomo Hospital, Osaka, 530-0005, Japan.
  • Yuya Yamada
    Department of Endocrinology and Metabolism, Sumitomo Hospital, Osaka, 530-0005, Japan.
  • Akihisa Imagawa
    Department of Internal Medicine (I), Osaka Medical College, Osaka, 569-8686, Japan.
  • Hiromi Iwahashi
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, 565-0871, Japan.
  • Iichiro Shimomura
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, 565-0871, Japan.

Keywords

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