Oxytocin ameliorates lipopolysaccharide-induced acute orchitis model: interplay of oxidative stress and inflammatory pathways.

Journal: Frontiers in pharmacology
Published Date: Jan 7, 2025

Abstract

INTRODUCTION: Lipopolysaccharide (LPS), a constituent of the outer membrane of Gram-negative bacteria, is a powerful inducer of systemic inflammation and has been extensively utilized in experimental models to simulate inflammatory responses and septic disorders. Recent research indicates that oxytocin (OXY), a neuropeptide typically linked to social bonding and reproductive functions, may influence inflammatory processes. This work examines the impact of OXY on LPS-induced testicular damage, aiming to elucidate its therapeutic potential in addressing inflammatory disorders and broadening the comprehension of its functions beyond conventional neuroendocrine roles.

Authors

  • Mohamed El-Sherbiny
    Department of Basic Medical Sciences, College of Medicine, AlMaarefa University, Riyadh, Saudi Arabia.
  • Hany A Elkattawy
    Department of Basic Medical Sciences, College of Medicine, AlMaarefa University, Riyadh, Saudi Arabia.
  • Shimaa Hadhoud
    Department of Physiology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
  • Ahmed N Nasr
    Department of Anatomy, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
  • Ateya M Ibrahim
    College of Nursing, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia.
  • Omar Z Ameer
    Department of Pharmaceutical Sciences, College of Pharmacy, Alfaisal University, Riyadh, Saudi Arabia.
  • Noorhan Alsaleebi
    Department of Basic Medical Sciences, College of Medicine, AlMaarefa University, Riyadh, Saudi Arabia.
  • Joud Asfari
    Department of Basic Medical Sciences, College of Medicine, AlMaarefa University, Riyadh, Saudi Arabia.
  • Madaniah O Zakari
    Department of Basic Medical Sciences, College of Medicine, Taibah University, Medinah, Saudi Arabia.
  • Moaz A Mojaddidi
    Department of Basic Medical Sciences, College of Medicine, Taibah University, Medinah, Saudi Arabia.
  • Ehab K Ali
    Department of Anatomy and Embryology, Faculty of Medicine, AL-Azhar University, New Damietta, Egypt.
  • Hailah M Almohaimeed
    Department of Basic Sciences, College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
  • Ahmed Abdeen
    Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Toukh, Egypt.
  • Sahar K Ali
    Department of Medical Pharmacology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
  • Mamdouh Eldesoqui
    Department of Basic Medical Sciences, College of Medicine, AlMaarefa University, Riyadh, Saudi Arabia.

Keywords

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