Potentiation of antibiotic activity by Mast. front of strains and .

Journal: Saudi journal of biological sciences
Published Date: Jan 14, 2016

Abstract

The development of new drugs from plants is an interesting alternative approach to overcoming microbial resistance. shows resistance to diseases and pests and a higher concentration of chemical components that may be useful in the pharmaceutical industry. We investigated the potential antimicrobial and antibiotic-modifying activity of hydroalcoholic extracts of leaves, stems, bark, pulp and seeds of . The extracts were prepared by homogenization of material in 50% ethanol. Minimum inhibitory concentration (MIC) was determined by the broth dilution method, and the bacterial strains tested were and . Antibiotic-modifying activity was evaluated against the strains 03 and 08, using a subinhibitory concentration of extract. The antibiotics tested were: amikacin, gentamicin, ampicillin, potassium benzylpenicillin and oxacillin. The extracts did not show antimicrobial activity of clinical relevance, where the MIC was equal to or greater than 1024 μg/mL. showed 13 events, while showed only 4 events. Among these events, 14 involved synergistic activity, potentiating the effect of the antibiotics, and only 3 events demonstrated antagonistic activity toward ampicillin. Hydroalcoholic extracts are potential antimicrobial agents when combined with conventional drugs little utilized in treatment.

Authors

  • Ana Luiza A Siebra
    Laboratory of Pharmacology and Molecular Chemistry and Laboratory of Pharmacology of Natural Products, Center of Biological Sciences and Health, Regional University of Cariri, Crato, CE, Brazil.
  • Larissa R Oliveira
    Laboratory of Pharmacology and Molecular Chemistry and Laboratory of Pharmacology of Natural Products, Center of Biological Sciences and Health, Regional University of Cariri, Crato, CE, Brazil.
  • Anita O B P B Martins
    Laboratory of Pharmacology and Molecular Chemistry and Laboratory of Pharmacology of Natural Products, Center of Biological Sciences and Health, Regional University of Cariri, Crato, CE, Brazil.
  • David C Siebra
    Federal University of Ceará, Campus Cariri, Barbalha, CE, Brazil.
  • Rosimeire S Albuquerque
    Laboratory of Microbiology and Molecular Biology, Regional University of Cariri, Crato, CE, Brazil.
  • Izabel Cristina Santiago Lemos
    Laboratory of Pharmacology and Molecular Chemistry and Laboratory of Pharmacology of Natural Products, Center of Biological Sciences and Health, Regional University of Cariri, Crato, CE, Brazil.
  • Gyllyandeson A Delmondes
    Laboratory of Pharmacology and Molecular Chemistry and Laboratory of Pharmacology of Natural Products, Center of Biological Sciences and Health, Regional University of Cariri, Crato, CE, Brazil.
  • Saulo R Tintino
    1 Universidade Regional do Cariri, Crato, Brasil.
  • Fernando G Figueredo
    Laboratory of Microbiology and Molecular Biology, Regional University of Cariri, Crato, CE, Brazil.
  • Jose Galberto M da Costa
    Laboratory of Research in Natural Products, Center of Biological Sciences and Health, University of the Region of Cariri, Crato, CE, Brazil.
  • Henrique D M Coutinho
    1 Universidade Regional do Cariri, Crato, Brasil.
  • Irwin R A Menezes
    1 Universidade Regional do Cariri, Crato, Brasil.
  • Cicero F B Felipe
    Laboratory of Pharmacology and Molecular Chemistry and Laboratory of Pharmacology of Natural Products, Center of Biological Sciences and Health, Regional University of Cariri, Crato, CE, Brazil.
  • Marta R Kerntopf
    Pharmacology of Natural Products Laboratory, Regional University of Cariri-Campus of Pimenta, 63105-010, Crato, CE, Brazil.

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