Gintonin absorption in intestinal model systems.

Journal: Journal of ginseng research
Published Date: Dec 19, 2016

Abstract

BACKGROUND: Recently, we identified a novel ginseng-derived lysophosphatidic acid receptor ligand, called gintonin. We showed that gintonin induces [Ca]i transient-mediated morphological changes, proliferation, and migration in cells expressing lysophosphatidic acid receptors and that oral administration of gintonin exhibits anti-Alzheimer disease effects in model mice. However, little is known about the intestinal absorption of gintonin. The aim of this study was to investigate gintonin absorption using two model systems.

Authors

  • Byung-Hwan Lee
    Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
  • Sun-Hye Choi
    Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
  • Hyeon-Joong Kim
    Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
  • Sang-Deuk Park
    Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
  • Hyewhon Rhim
    Center for Neuroscience, Korea Institute of Science and Technology, Seoul, Republic of Korea.
  • Hyoung-Chun Kim
    Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chuncheon, Korea.
  • Sung-Hee Hwang
    Department of Pharmaceutical Engineering, College of Health Sciences, Sangji University, Wonju, Republic of Korea.
  • Seung-Yeol Nah
    Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.

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