Korean Red Ginseng extract induces angiogenesis through activation of glucocorticoid receptor.

Journal: Journal of ginseng research
Published Date: Sep 8, 2016

Abstract

BACKGROUND: Our previous studies have demonstrated that ginsenoside-Rg1 can promote angiogenesis and through activation of the glucocorticoid receptor (GR). Furthermore, microRNA (miRNA) expression profiling has shown that Rg1 can modulate the expression of a subset of miRNAs to induce angiogenesis. Moreover, Rb1 was shown to be antiangiogenic through activation of a different pathway. These studies highlight the important functions of miRNAs on ginseng-regulated physiological processes. The aim of this study was to determine the angiogenic properties of Korean Red Ginseng extract (KGE).

Authors

  • Wai-Nam Sung
    Department of Biology, Hong Kong Baptist University, Hong Kong.
  • Hoi-Hin Kwok
    Department of Biology, Hong Kong Baptist University, Hong Kong.
  • Man-Hee Rhee
    Laboratory of Physiology and Cell Signaling, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea.
  • Patrick Ying-Kit Yue
    Department of Biology, Hong Kong Baptist University, Hong Kong.
  • Ricky Ngok-Shun Wong
    Department of Biology, Hong Kong Baptist University, Hong Kong.

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