Integration of single-cell transcriptomics and bulk transcriptomics to explore prognostic and immunotherapeutic characteristics of nucleotide metabolism in lung adenocarcinoma.

Journal: Frontiers in genetics
Published Date: Jan 8, 2025

Abstract

BACKGROUND: Lung adenocarcinoma (LUAD) is a highly aggressive tumor with one of the highest morbidity and mortality rates in the world. Nucleotide metabolic processes are critical for cancer development, progression, and alteration of the tumor microenvironment. However, the effect of nucleotide metabolism on LUAD remains to be thoroughly investigated.

Authors

  • Kai Zhang
    Anhui Province Key Laboratory of Respiratory Tumor and Infectious Disease, First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
  • Luyao Wang
    Department of Genetics, School of Life Sciences, Bengbu Medical University, Bengbu, China.
  • Huili Chen
    Research Center of Clinical Laboratory Science, Bengbu Medical University, Bengbu, China.
  • Lili Deng
    Anhui Province Key Laboratory of Respiratory Tumor and Infectious Disease, First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
  • Mengling Hu
    Department of Genetics, School of Life Sciences, Bengbu Medical University, Bengbu, China.
  • Ziqiang Wang
    Research Center of Clinical Laboratory Science, Bengbu Medical University, Bengbu, China.
  • Yiluo Xie
    Department of Clinical Medicine, Bengbu Medical University, Bengbu, China.
  • Chaoqun Lian
    Research Center of Clinical Laboratory Science, Bengbu Medical University, Bengbu, China.
  • Xiaojing Wang
    Anhui Province Key Laboratory of Respiratory Tumor and Infectious Disease, First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
  • Jing Zhang
    MOEMIL Laboratory, School of Optoelectronic Information, University of Electronic Science and Technology of China, Chengdu, China.

Keywords

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