Isolation and Cytotoxic Investigation of Flacourtin from Oncoba spinosa.
Journal:
Medicines (Basel, Switzerland)
Published Date:
Dec 6, 2016
Abstract
an endangered medicinal plant whose secondary metabolites have not been extensively profiled, and which is hitherto yet to be examined for cytotoxicity, is being investigated in this study. Leaves of (800 g) were extracted with 95% aqueous methanol. The crude extract was partitioned with n-hexane and the resultant defatted extract was extensively chromatographed on silica gel to yield compound which was subjected to spectroscopic analysis. A brine shrimps lethality test was used to establish the cytotoxicity potentials of the isolated compound and the plant extracts. Compound was elucidated as flacourtin, 3-hydroxy-4-hydroxymethylphenyl-6--benzoyl-β-d-glucopyranoside. The LD values obtained were less than 1000 µg/mL for flacourtin and the plant extracts. Flacourtin is being reported for the first time in the . The preliminary toxicity assay indicated that flacourtin and the plant extracts were not cytotoxic; thus, the tradomedicinal uses of the plant may portend no danger.
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