Protective effect of ginsenosides Rk3 and Rh4 on cisplatin-induced acute kidney injury and .

Journal: Journal of ginseng research
Published Date: Apr 6, 2016

Abstract

BACKGROUND: Nephrotoxicity is the major side effect in cisplatin chemotherapy. Previously, we reported that the ginsenosides Rk3 and Rh4 reduced cisplatin toxicity on porcine renal proximal epithelial tubular cells (LLC-PK1). Here, we aimed to evaluate the protective effect of ginsenosides Rk3 and Rh4 on kidney function and elucidate their antioxidant effect using and models of cisplatin-induced acute renal failure.

Authors

  • Seung-Hoon Baek
    College of Pharmacy, Ajou University, Suwon, Republic of Korea.
  • Byong-Kyu Shin
    College of Pharmacy, Seoul National University, Republic of Korea.
  • Nam Jae Kim
    East-West Medical Research Institute, Kyung Hee University Medical Center, Seoul, Republic of Korea.
  • Sun-Young Chang
    College of Pharmacy, Ajou University, Suwon, Republic of Korea.
  • Jeong Hill Park
    College of Pharmacy, Seoul National University, Republic of Korea.

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