High Interleukin 27 Production is Associated with Early Clinical Stage and Localized Disease in Patients with Melanoma.

Journal: Journal of medical biochemistry
Published Date: Nov 2, 2016

Abstract

BACKGROUND: The immune response in patients with melanoma is an important focus of research due to the tumor's resistance and immunotherapy possibilities. IL-27 is one of the cytokines with antitumor properties. The role of IL-27 in the pathogenesis of melanoma is still unclear. The aim of this study was to examine the association between serum IL-27 levels and the clinical parameters of melanoma patients.

Authors

  • Jelena Pantic Bisevac
    Institute of Medical Biochemistry, Military Medical Academy, Belgrade, Serbia.
  • Ivan Stanojevic
    Institute for Medical Research, Military Medical Academy, Belgrade, Serbia.
  • Zeljko Mijuskovic
    Clinic of Dermatology, Military Medical Academy, Belgrade, Serbia.
  • Tatjana Banovic
    Department of Immunology, SA Pathology, Royal Adelaide Hospital, Adelaide, Australia.
  • Mirjana Djukic
    Department of Toxicology, Faculty of Pharmacy, University of Belgrade, Serbia.
  • Danilo Vojvodic
    Institute for Medical Research, Military Medical Academy, Belgrade, Serbia.

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