Verifying Sarcoidosis Activity: Chitotriosidase versus ACE in Sarcoidosis - a Case-control Study.

Journal: Journal of medical biochemistry
Published Date: Nov 2, 2016

Abstract

BACKGROUND: Until now, a proper biomarker(s) to evaluate sarcoidosis activity has not been recognized. The aims of this study were to evaluate the sensitivity and specificity of the two biomarkers of sarcoidosis activity already in use (serum angiotensin converting enzyme - ACE and serum chitotriosidase) in a population of 430 sarcoidosis patients. The activities of these markers were also analyzed in a group of 264 healthy controls.

Authors

  • Spasoje Popević
    Medical Faculty, University of Belgrade, Serbia.
  • Zorica Šumarac
    Center for Medical Biochemistry, Clinical Center of Serbia, Belgrade, Serbia.
  • Dragana Jovanović
    Medical Faculty, University of Belgrade, Serbia.
  • Dragan Babić
    Institute of Medical Statistics and Informatics, Medical Faculty, University of Belgrade, Serbia.
  • Mihailo Stjepanović
    Clinic of Pulmonary Diseases, Clinical Center of Serbia, Belgrade, Serbia.
  • Snežana Jovičić
    Center for Medical Biochemistry, Clinical Center of Serbia, Belgrade, Serbia.
  • Dragana Šobić-Šaranović
    Medical Faculty, University of Belgrade, Serbia.
  • Snežana Filipović
    Clinic of Pulmonary Diseases, Clinical Center of Serbia, Belgrade, Serbia.
  • Branko Gvozdenović
    Department of Clinical Management, PPD, Serbia.
  • Maja Omčikus
    Clinic of Pulmonary Diseases, Clinical Center of Serbia, Belgrade, Serbia.
  • Anđela Milovanović
    Clinic for Physical Medicine and Rehabilitation, Clinical Center of Serbia, Belgrade, Serbia.
  • Jelica Videnović-Ivanov
    Clinic of Pulmonary Diseases, Clinical Center of Serbia, Belgrade, Serbia.
  • Ana Radović
    Center for Medical Biochemistry, Clinical Center of Serbia, Belgrade, Serbia.
  • Vladimir Žugić
    Medical Faculty, University of Belgrade, Serbia.
  • Violeta Mihailović-Vučinić
    Medical Faculty, University of Belgrade, Serbia.

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