Artificial intelligence-driven identification and mechanistic exploration of synergistic anti-breast cancer compound combinations from L.- Hand.-Mazz. herb pair.

Journal: Frontiers in pharmacology
Published Date:

Abstract

INTRODUCTION: The L. (PVL) and Hand.-Mazz. (TH) herb pair, which is commonly used in traditional Chinese medicine (TCM), has been applied for the treatment of breast cancer. Although its efficacy is validated, the synergistic anti-breast cancer compound combinations within this herb pair and their underlying mechanisms of action remain unclear.

Authors

  • Chunlai Feng
    School of Pharmacy, Jiangsu University, Zhenjiang, China.
  • Jiaxi Cheng
    School of Pharmacy, Jiangsu University, Zhenjiang, China.
  • Mengqiu Sun
    School of Pharmacy, Jiangsu University, Zhenjiang, China.
  • Chunxue Qiao
    School of Pharmacy, Jiangsu University, Zhenjiang, China.
  • Qiuqi Feng
    School of Pharmacy, Jiangsu University, Zhenjiang, China.
  • Naying Fang
    School of Pharmacy, Jiangsu University, Zhenjiang, China.
  • Yingying Ge
    School of Pharmacy, Jiangsu University, Zhenjiang, China.
  • Mengjie Rui
    School of Pharmacy, Jiangsu University, Zhenjiang, China.

Keywords

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