Exploring the shared gene signatures and mechanism among three autoimmune diseases by bulk RNA sequencing integrated with single-cell RNA sequencing analysis.

Journal: Frontiers in molecular biosciences
Published Date: Jan 7, 2025

Abstract

BACKGROUND: Emerging evidence underscores the comorbidity mechanisms among autoimmune diseases (AIDs), with innovative technologies such as single-cell RNA sequencing (scRNA-seq) significantly advancing the explorations in this field. This study aimed to investigate the shared genes among three AIDs-Multiple Sclerosis (MS), Systemic Lupus Erythematosus (SLE), and Rheumatoid Arthritis (RA) using bioinformatics databases, and to identify potential biomarkers for early diagnosis.

Authors

  • Xiaofang Liu
    Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
  • Bin Li
    Department of Magnetic Resonance Imaging (MRI), Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
  • Yuxi Lin
    Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
  • Xueying Ma
    Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
  • Yingying Liu
    Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
  • Lili Ma
    Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
  • Xiaomeng Ma
    Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
  • Xia Wang
    Department of Neurology, The Sixth People's Hospital of Huizhou City, Huizhou, China.
  • Nanjing Li
    Department of Neurology, The Sixth People's Hospital of Huizhou City, Huizhou, China.
  • Xiaoyun Liu
    Department of General Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
  • Xiaohong Chen
    Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

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