Repetitive head impact exposure and later-life plasma total tau in former National Football League players.

Journal: Alzheimer's & dementia (Amsterdam, Netherlands)
Published Date: Dec 10, 2016

Abstract

INTRODUCTION: Blood protein analysis of total tau (t-tau) may be a practical screening biomarker for chronic traumatic encephalopathy (CTE), a neurodegenerative tauopathy associated with repetitive head impact (RHI) exposure. We examined plasma t-tau in symptomatic former National Football League (NFL) players compared with controls and the relationship between RHI exposure and later-life plasma t-tau.

Authors

  • Michael L Alosco
    Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, MA, USA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
  • Yorghos Tripodis
    Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, MA, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
  • Johnny Jarnagin
    Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, MA, USA.
  • Christine M Baugh
    Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, MA, USA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA; Interfaculty Initiative in Health Policy, Harvard University Boston, MA, USA.
  • Brett Martin
    Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, MA, USA; Data Coordinating Center, Boston University School of Public Health, Boston, MA, USA.
  • Christine E Chaisson
    Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, MA, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA; Data Coordinating Center, Boston University School of Public Health, Boston, MA, USA.
  • Nate Estochen
    Quanterix Corporation, Lexington, MA, USA.
  • Linan Song
    Quanterix Corporation, Lexington, MA, USA.
  • Robert C Cantu
    Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, MA, USA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA; Department of Neurosurgery, Boston University School of Medicine, Boston, MA, USA.
  • Andreas Jeromin
    Quanterix Corporation, Lexington, MA, USA.
  • Robert A Stern
    Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, MA, USA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA; Department of Neurosurgery, Boston University School of Medicine, Boston, MA, USA; Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA.

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