Mometasone Furoate Suppresses PMA-Induced MUC-5AC and MUC-2 Production in Human Airway Epithelial Cells.

Journal: Tuberculosis and respiratory diseases
Published Date: Dec 30, 2016

Abstract

BACKGROUND: Mucus hypersecretion from airway epithelium is a characteristic feature of airway inflammatory diseases. Tumor necrosis factor α (TNF-α) regulates mucin synthesis. Glucocorticoids including mometasone fuorate (MF) have been used to attenuate airway inflammation. However, effects of MF on mucin production have not been reported.

Authors

  • Orapan Poachanukoon
    Department of Pediatrics, Faculty of Medicine, Thammasat University (Rangsit Center), Pathum Thani, Thailand.
  • Sittichai Koontongkaew
    Oral Biology Laboratory, Faculty of Dentistry, Thammasat University (Rangsit Center), Pathum Thani, Thailand.
  • Paopanga Monthanapisut
    Oral Biology Laboratory, Faculty of Dentistry, Thammasat University (Rangsit Center), Pathum Thani, Thailand.
  • Napaporn Pattanacharoenchai
    Oral Biology Laboratory, Faculty of Dentistry, Thammasat University (Rangsit Center), Pathum Thani, Thailand.

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