Topographical and depth-dependent glycosaminoglycan concentration in canine medial tibial cartilage 3 weeks after anterior cruciate ligament transection surgery-a microscopic imaging study.

Journal: Quantitative imaging in medicine and surgery
Published Date: Dec 1, 2016

Abstract

BACKGROUND: Medical imaging has become an invaluable tool to diagnose damage to cartilage. Depletion of glycosaminoglycans (GAG) has been shown to be one of the early signs of cartilage degradation. In order to investigate the topographical changes in GAG concentration caused by the anterior cruciate ligament transection (ACLT) surgery in a canine model, microscopic magnetic resonance imaging (µMRI) and microscopic computed tomography (µCT) were used to measure the GAG concentration with correlation from a biochemical assay, inductively coupled plasma optical emission spectroscopy (ICP-OES), to understand where the topographical and depth-dependent changes in the GAG concentration occur.

Authors

  • Daniel Mittelstaedt
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, MI 48309, USA.
  • David Kahn
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, MI 48309, USA.
  • Yang Xia
    The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China.

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