Curcumin nanocrystals ameliorate ferroptosis of diabetic nephropathy through glutathione peroxidase 4.

Journal: Frontiers in pharmacology
Published Date: Jan 6, 2025

Abstract

OBJECTIVE: The aim of this study was to investigate the effect of curcumin nanocrystals (Cur-NCs) on ferroptosis in high-glucose (HG)-induced HK-2 cells and streptozotocin (STZ)-induced diabetic nephropathy model (DN) rats. The purpose is to determine whether Cur NCs can become a promising treatment option for diabetes nephropathy by reducing ferroptosis.

Authors

  • Mengjiao Xue
    School of Clinical Medicine, Hangzhou Medical College, Hangzhou, China.
  • Yiwei Tian
    School of Pharmacy, Shanghai Jiaotong University, Shanghai, China.
  • Hua Zhang
    School of Clinical Medicine, Hangzhou Medical College, Hangzhou, China.
  • Shijie Dai
    College of Life Science, Academy of Chinese Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
  • Yangsheng Wu
    College of Life Science, Academy of Chinese Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
  • Juan Jin
    School of Clinical Medicine, Hangzhou Medical College, Hangzhou, China.
  • Jian Chen
    School of Pharmacy, Shanghai Jiaotong University, Shanghai, China.

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