Xixin Decoction's novel mechanism for alleviating Alzheimer's disease cognitive dysfunction by modulating amyloid-β transport across the blood-brain barrier to reduce neuroinflammation.

Journal: Frontiers in pharmacology
Published Date: Jan 6, 2025

Abstract

PURPOSE: Xixin Decoction (XXD) is a classical formula that has been used to effectively treat dementia for over 300 years. Modern clinical studies have demonstrated its significant therapeutic effects in treating Alzheimer's disease (AD) without notable adverse reactions. Nevertheless, the specific mechanisms underlying its efficacy remain to be elucidated. This investigation sought to elucidate XXD's impact on various aspects of AD pathology, including blood-brain barrier (BBB) impairment, neuroinflammatory processes, and amyloid-β (Aβ) deposition, as well as the molecular pathways involved in these effects.

Authors

  • Chaokai Yang
    The First Clinical Medical College of Shaanxi University of Chinese Medicine, Xianyang, China.
  • Enlong Zhao
    The First Clinical Medical College of Shaanxi University of Chinese Medicine, Xianyang, China.
  • Hu Zhang
    Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.
  • Liqi Duan
    The First Clinical Medical College of Shaanxi University of Chinese Medicine, Xianyang, China.
  • Xinyue Han
    The First Clinical Medical College of Shaanxi University of Chinese Medicine, Xianyang, China.
  • Hongli Ding
    The First Clinical Medical College of Shaanxi University of Chinese Medicine, Xianyang, China.
  • Yan Cheng
    The First Clinical Medical College of Shaanxi University of Chinese Medicine, Xianyang, China.
  • Dengkun Wang
    The First Clinical Medical College of Shaanxi University of Chinese Medicine, Xianyang, China.
  • Xiaojing Lei
    Key Research Laboratory for Prevention and Treatment of Cerebrospinal diseases, Shaanxi Provincial Administration of Traditional Chinese Medicine, Xianyang, China.
  • Yongchang Diwu
    Key Research Laboratory for Prevention and Treatment of Cerebrospinal diseases, Shaanxi Provincial Administration of Traditional Chinese Medicine, Xianyang, China.

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