Enhanced fibrotic potential of COL1A1NR4A1 fibroblasts in ischemic heart revealed by transcriptional dynamics heterogeneity analysis at both bulk and single-cell levels.

Journal: Frontiers in cardiovascular medicine
Published Date: Jan 6, 2025

Abstract

BACKGROUND: Fibroblasts in the fibrotic heart exhibit a heterogeneous biological behavior. The specific subsets of fibroblasts that contribute to progressive cardiac fibrosis remain unrevealed. Our aim is to identify the heart fibroblast (FB) subsets that most significantly promote fibrosis and the related critical genes as biomarkers for ischemic heart disease.

Authors

  • Cheng Luo
    Department of Cardiology, Liuzhou Workers' Hospital, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, China.
  • Baoping Tan
    Department of Cardiology, Liuzhou Workers' Hospital, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, China.
  • Luoxiang Chu
    Department of Cardiology, Liuzhou Workers' Hospital, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, China.
  • Liqiang Chen
    Department of Oncology, Liuzhou Workers' Hospital,The Fourth Affiliated Hospital of Guangxi Medical University, Liuazhou, China.
  • Xinglong Zhong
    Department of Cardiology, Liuzhou Workers' Hospital, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, China.
  • Yangyang Jiang
    Rehabilitation Department, Liuzhou Workers' Hospital,The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, China.
  • Yuluan Yan
    Department of Cardiology, Liuzhou Workers' Hospital, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, China.
  • Fanrui Mo
    Department of Cardiology, Liuzhou Workers' Hospital, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, China.
  • Hong Wang
    Department of Cardiology, Liuzhou Workers' Hospital, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, China.
  • Fan Yang
    School of Electrical Engineering and Automation, Jiangsu Normal University, Xuzhou, China.

Keywords

No keywords available for this article.

External Resources

Popular Topics
Recent Journals