The Risk of Hepatocellular Carcinoma After Directly Acting Antivirals for Hepatitis C Virus Treatment in Liver Transplanted Patients: Is It Real?

Journal: Hepatitis monthly
Published Date: Oct 30, 2016

Abstract

INTRODUCTION: Since directly acting antivirals (DAAs) for treatment of hepatitis C virus (HCV) were introduced, conflicting data emerged about the risk of hepatocellular carcinoma (HCC) after interferon (IFN)-free treatments. We present a case of recurrent, extra-hepatic HCC in a liver-transplanted patient soon after successful treatment with DAAs, along with a short review of literature.

Authors

  • Alessio Strazzulla
    Unit of Infectious and Tropical Diseases, Department of Medical and Surgical Sciences, "Magna Graecia" University, Catanzaro, Italy.
  • Rosa Maria Rita Iemmolo
    Liver and Multivisceral Transplant Center, University of Modena and Reggio Emilia, Modena, Italy.
  • Ennio Carbone
    Experimental and Clinic Medicine, Department of Experimental and Clinical Medicine, "Magna Graecia" University, Catanzaro, Italy; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
  • Maria Concetta Postorino
    Unit of Infectious and Tropical Diseases, Department of Medical and Surgical Sciences, "Magna Graecia" University, Catanzaro, Italy.
  • Maria Mazzitelli
    Unit of Infectious and Tropical Diseases, Department of Medical and Surgical Sciences, "Magna Graecia" University, Catanzaro, Italy.
  • Mario De Santis
    Unit of Radiology, University of Modena and Reggio Emilia, Modena, Italy.
  • Fabrizio Di Benedetto
    Liver and Multivisceral Transplant Center, University of Modena and Reggio Emilia, Modena, Italy.
  • Costanza Maria Cristiani
    Experimental and Clinic Medicine, Department of Experimental and Clinical Medicine, "Magna Graecia" University, Catanzaro, Italy.
  • Chiara Costa
    Unit of Infectious and Tropical Diseases, Department of Medical and Surgical Sciences, "Magna Graecia" University, Catanzaro, Italy.
  • Vincenzo Pisani
    Unit of Infectious and Tropical Diseases, Department of Medical and Surgical Sciences, "Magna Graecia" University, Catanzaro, Italy.
  • Carlo Torti
    Unit of Infectious and Tropical Diseases, Department of Medical and Surgical Sciences, "Magna Graecia" University, Catanzaro, Italy.

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