Acta pharmaceutica Sinica. B
Nov 5, 2023
Efficient translation mediated by the 5' untranslated region (5' UTR) is essential for the robust efficacy of mRNA vaccines. However, the 1-methyl-pseudouridine (m1) modification of mRNA can impact the translation efficiency of the 5' UTR. We discove...
Acta pharmaceutica Sinica. B
Dec 2, 2021
Lipid nanoparticle (LNP) is commonly used to deliver mRNA vaccines. Currently, LNP optimization primarily relies on screening ionizable lipids by traditional experiments which consumes intensive cost and time. Current study attempts to apply computat...
Acta pharmaceutica Sinica. B
Nov 5, 2021
Transient receptor potential (TRP) channels are one primary type of calcium (Ca) permeable channels, and those relevant transmembrane and intracellular TRP channels were previously thought to be mainly associated with the regulation of cardiovascular...
Acta pharmaceutica Sinica. B
Sep 10, 2021
Drug repurposing or repositioning has been well-known to refer to the therapeutic applications of a drug for another indication other than it was originally approved for. Repurposing non-oncology small-molecule drugs has been increasingly becoming an...
Acta pharmaceutica Sinica. B
Dec 30, 2019
The application of nanotechnology for antimicrobial delivery has capacity to improve antibacterial efficacy. Currently, the usage of various inorganic and organic carriers, such as metal ions, nano-silicon and surfactants, might increase the potentia...
Acta pharmaceutica Sinica. B
Aug 22, 2019
Ricin is a highly toxic type 2 ribosome-inactivating protein (RIP) which is extracted from the seeds of castor beans. Ricin is considered a potential bioterror agent and no effective antidote for ricin exists so far. In this study, by structural modi...
Acta pharmaceutica Sinica. B
Sep 28, 2018
Current pharmaceutical formulation development still strongly relies on the traditional trial-and-error methods of pharmaceutical scientists. This approach is laborious, time-consuming and costly. Recently, deep learning has been widely applied in ma...
Acta pharmaceutica Sinica. B
Dec 18, 2017
With the rapid development and wide application of traditional Chinese medicine injection (TCMI), a number of adverse events of some TCMIs have incessantly been reported and have drawn broad attention in recent years. Establishing effective and pract...
Acta pharmaceutica Sinica. B
Sep 13, 2017
Traditional Chinese herbs (TCH) are currently gaining attention in disease prevention and health care plans. However, their general bitter taste hinders their use. Despite the development of a variety of taste evaluation methods, it is still a major ...
Acta pharmaceutica Sinica. B
Dec 30, 2016
An effective herbal medicinal prescription of Shengjiang Xiexin decoction (SXD) was used in treating the inflammatory bowel disease in clinic. In this study, an ultrafast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS) method was develope...