AIMC Journal:
Cell discovery

Showing 1 to 3 of 3 articles

Cross-protective human antibodies against the Mpox virus discovered through structure-guided screening.

Cell discovery
Mpox virus (MPXV) poses an increasing global health threat, as underscored by two World Health Organization declarations of Public Health Emergencies of International Concern, particularly after the emergence of a novel Clade Ib strain that exhibited...

Decoding the role of chromatin context in the off-target effects of CRISPR gene editing with EGOLD.

Cell discovery
Despite the power of CRISPR in genome editing, its clinical application is limited by off-target effects; these effects are currently difficult to evaluate at the genome level but are likely to involve chromatin context. Here, we developed the Endoge...

Integrative spatial profiling pipeline for determining TME architectures in archival clinical specimens using CmTSA superplex technology.

Cell discovery
The tumor microenvironment (TME) comprises diverse cellular components that spatially interact to form distinct functional niches (FNs). Profiling these TME spatial features has proven to be a critical approach for correlating tumor progression and t...