The pituitary neuroendocrine tumour (PitNET) immune microenvironment (IME) has become a recent focus of research interest. Multiplex immunofluorescence combined with digital image analysis is a powerful technique to interrogate the IME. Processes suc...
Endocrine therapies initially enforce lineage identity in hormone-driven cancers, yet sustained hormonal suppression often triggers a coordinated systems-level rewiring through lineage plasticity. Previously, lineage plasticity has been characterized...
Artificial intelligence (AI) is rapidly moving from conceptual innovation to high-performing algorithms across the pituitary patient pathway, promising benefit to patients, endocrinologists and surgeons alike. Pre-operatively, machine learning applie...
Hereditary endocrine neoplastic syndromes require structured, lifelong surveillance owing to their multisystem involvement, variable penetrance, and high risk of multifocal and metastatic disease. Functional imaging (FI) is now integral to their mana...
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