IEEE transactions on computational biology and bioinformatics
Jun 3, 2026
Accurate identification of RNA-protein binding sites is crucial for understanding gene regulation and disease mechanisms. However, existing deep learning models still face challenges in synergistically modeling multi-scale sequence motifs and dynamic...
IEEE transactions on computational biology and bioinformatics
May 27, 2026
Few-shot molecular property prediction is a persisting challenge in many biology-related tasks, because the same molecule may exhibit different properties (e.g., active or inactive) in different tasks. Existing methods view all atoms as equally impor...
IEEE transactions on computational biology and bioinformatics
May 27, 2026
Spatially Resolved Transcriptomics (SRT) has revolutionized our understanding of gene expression within tissue microenvironments, yet accurately deciphering spatiotemporal structures-encompassing spatial domain identification, trajectory inference, a...
IEEE transactions on computational biology and bioinformatics
May 26, 2026
Molecular fragments play a crucial role in molecular property prediction. However, most existing deep learning approaches rely heavily on expert-defined substructural patterns, limiting their ability to identify novel or latent fragments. This constr...
IEEE transactions on computational biology and bioinformatics
May 25, 2026
DNA methylation is a key epigenetic modification with diagnostic and prognostic relevance across a wide range of diseases, particularly cancer. Modern array-based technologies enable high-throughput quantification of methylation states at hundreds of...
IEEE transactions on computational biology and bioinformatics
May 21, 2026
Distinguishing the activation and inhibition mechanisms between drugs and targets can reveal the potential regulatory pathways of target functions, which is crucial in drug discovery and development. Although numerous deep learning based computationa...
IEEE transactions on computational biology and bioinformatics
May 20, 2026
Persistent viruses like Influenza, HIV, and Coronavirus exemplify the challenge of viral escape, significantly hindering the development of long-lasting vaccines and effective treatments. This study leverages a Long Short-Term Memory (LSTM) based dee...
IEEE transactions on computational biology and bioinformatics
May 14, 2026
The discovery of CRISPR-Cas system has significantly advanced genome editing, offering vast applications in medical treatments and life sciences research. Despite their immense potential, the existing CRISPR-Cas systems still face challenges concerni...
IEEE transactions on computational biology and bioinformatics
May 11, 2026
Breast cancer remains a global health challenge, and early detection is crucial for improving survival rates. However, traditional biomarker detection methods in machine learning face challenges such as high false positives, large gene datasets, and ...
IEEE transactions on computational biology and bioinformatics
May 8, 2026
OBJECTIVE: This study aimed to develop a deep learning-based volition-detection model to automate the diagnostic process and improve neuromuscular disease classification using needle electromyography (nEMG) signals. METHODS: The model was developed u...