Journal of pharmaceutical analysis
Sep 12, 2020
Cystine is the primary source material for the synthesis of glutathione. However, the pharmacokinetics and tissue distribution of cystine are largely unknown. A surrogate analyte D-cystine was employed to generate calibration curves for the determina...
Journal of pharmaceutical analysis
Sep 5, 2020
Cyclic 3',5'-adenosine monophosphate (cAMP) and cyclic 3',5'-guanosine monophosphate (cGMP) are considered as potential biomarkers for Yin-Yang disharmony in traditional Chinese medicine. However, phosphodiesterase-mediated ex vivo degradation of the...
Journal of pharmaceutical analysis
Aug 15, 2020
Liquid chromatography tandem mass spectrometry (LC-MS/MS) has gradually become a promising alternative to ligand binding assay for the bioanalysis of biotherapeutic molecules, due to its rapid method development and high accuracy. In this study, we e...
Journal of pharmaceutical analysis
Aug 2, 2020
Astragali radix (AR, the dried root of ) is a popular herbal remedy in both China and the United States. The commercially available AR is commonly classified into premium graded (PG) and ungraded (UG) ones only according to the appearance. To uncover...
Journal of pharmaceutical analysis
Jul 3, 2020
A rapid GC-FID method was developed to simultaneously determine residual levels of triethylamine (TEA), 1,1,3,3-tetramethylguanidine (TMG), and diisopropylamine (DIPA) in the synthetic route of an active pharmaceutical ingredient (API). Due to the se...
Journal of pharmaceutical analysis
Apr 30, 2020
Nutrient recovery from source-separated human urine has attracted interest as it is rich in nitrogen and phosphorus that can be utilized as fertilizer. However, urine also contains pharmaceuticals, steroid hormones, etc. and their removal is crucial ...
Journal of pharmaceutical analysis
Dec 12, 2019
Emblic medicine is a popular natural source in the world due to its outstanding healthcare and therapeutic functions. Our preliminary results indicated that the quality of emblic medicines might have an apparent regional variation. A rapid and effect...
Journal of pharmaceutical analysis
Nov 14, 2019
(GF) and Praeparatum (SSP) are both medicine food homologies and widely used in Chinese clinical prescriptions together. The research investigated the pharmacokinetics of four iridoids in normal rats and isolfavones-fed rats, which were administere...
Journal of pharmaceutical analysis
Sep 17, 2019
In Korea and China, ilaprazole is a widely used proton pump inhibitor in the treatment of gastric ulcers. In this study, a specific and sensitive LC-MS/MS method has been developed and validated for the quantification of ilaprazole enantiomers in the...
Journal of pharmaceutical analysis
Jul 26, 2019
Karacoline is a compound found in the plant Reichb. Although Reichb is widely used for the treatment of pain, very few studies have been carried out on the use of karacoline due to its potential toxicity. In this study, we selected key matrix metal...