AIMC Journal:
Molecular brain

Showing 1 to 4 of 4 articles

Organoids as next-generation models for investigating intracranial tumours.

Molecular brain
Tumour organoids have emerged as important tools in brain tumour research, addressing long-standing limitations of conventional two-dimensional cultures, xenograft models, and genetically engineered mouse models. By preserving patient-specific geneti...

REST deficiency and neurogenic-to-gliogenic shift in down syndrome human cerebral organoids.

Molecular brain
Down syndrome (DS) features impaired cortical neurogenesis and excess gliogenesis, yet the temporal regulatory events driving this imbalance remain unclear. Here, we combine multi-timepoint transcriptomic analyses from publicly available datasets, ne...

Artificial intelligence-based biomarkers for the diagnosis and treatment of neurological conditions: a narrative review.

Molecular brain
Artificial intelligence (AI) is transforming biomarker discovery in neurology by overcoming key limitations of conventional approaches that are often slow, reductionist, and unable to integrate complex multimodal data. In this narrative review, we se...

Insights into the interplay between stroke and depression through lipid metabolism-related diagnostic genes.

Molecular brain
Stroke, a result of acute cerebrovascular disease that causes cerebral dysfunction, often coexists with depression or even major depressive disorder (MDD). Despite the recognized significance of lipid metabolism disorders in both stroke and depressio...