AIMC Journal:
Molecular carcinogenesis

Showing 1 to 5 of 5 articles

Elucidating the Association Between Gastric Cancer and Diabetes: Integrative Analysis of Epidemiological, Genetic, and Transcriptomic Data.

Molecular carcinogenesis
Gastric cancer and diabetes are two major global health challenges, and recent studies have indicated a potential association between these diseases. This study utilized NHANES database (2007-2016) to identify diseases linked to gastric cancer, with ...

A Progression-Associated Tumor-Reactive T-Cell Signature Predicts Immunotherapy Response and Reveals ICOS-High CD8 T-Cell Functional States in Head and Neck Squamous Cell Carcinoma.

Molecular carcinogenesis
Immune checkpoint blockade has improved outcomes for patients with head and neck squamous cell carcinoma (HNSCC), but reliable biomarkers for predicting therapeutic response remain limited. Tumor-reactive T-cell states are increasingly recognized as ...

DUSP9 Regulates Hepatoblastoma Progression With Implications for Diagnosis and Targeted Therapy.

Molecular carcinogenesis
This study investigated the mechanistic role of DUSP9 in hepatoblastoma (HB) development and progression to provide new insights into the diagnosis and treatment of pediatric HB. Pediatric HB mRNA expression data were obtained from the GEO database. ...

Comprehensive Multi-Omics Profiling of Tertiary Lymphoid Structures Reveals Immunogenetic Landscapes and Prognostic Subtypes in Lung Adenocarcinoma.

Molecular carcinogenesis
Tertiary lymphoid structures (TLSs) are key components of the tumor immune microenvironment and show prognostic relevance in many cancers. However, their genetic association with lung adenocarcinoma (LUAD) is still lacking. This study aims to constru...

B4GALT3 as a Key Glycosyltransferase Gene in Multiple Myeloma Progression: Insights From Bioinformatics, Machine Learning, and Experimental Validation.

Molecular carcinogenesis
Glycosylation abnormalities are critical in the progression of various cancers. However, their role in the onset and prognosis of multiple myeloma (MM) remains underexplored. This study aims to identify glycosyltransferase (GT)-related biomarkers and...