AIMC Journal:
Molecular therapy. Advances

Showing 1 to 2 of 2 articles

From epigenetic mark detection to rational design of epigenetic editing strategies.

Molecular therapy. Advances
Although cells within an organism share nearly identical genomes, their transcriptional programs differ markedly due to reversible chemical modifications known as epigenetic marks. These marks, including DNA methylation and histone modifications, reg...

AI-engineered AAV capsid enables intravitreal delivery for the treatment of diverse retinal degenerations.

Molecular therapy. Advances
Retinal degenerations, including Leber's congenital amaurosis type 1 (LCA1) and wet age-related macular degeneration (wAMD), represent leading causes of vision impairment and blindness, driven by a range of factors, including genetic mutations and pa...