AIMC Journal:
bioRxiv

Showing 1051 to 1060 of 4938 articles

Cell-type-specific cortical feedback coordinates hierarchical credit assignment

bioRxiv Jun 17, 2026
Learning is thought to arise from synaptic modifications embedded in brain-wide circuits, yet how such circuits coordinate plasticity to support complex behaviour is not known. Inspired by deep learning, we propose a theory in which pathway-specific ...
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Predicting Mouse Lifespan-Extending Chemical Compounds with Machine Learning

bioRxiv Jun 17, 2026
Pharmacological interventions targeting the biological processes of ageing hold significant potential to extend healthspan and promote longevity. This, to our knowledge, is the first study that uses Machine Learning models trained specifically on mou...
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Machine learning-guided olivetolic acid cyclase engineering enables tailored cannabinoid biosynthesis in yeast

bioRxiv Jun 17, 2026
Cannabinoids comprise a diverse class of bioactive natural products with important therapeutic potential, but efficient microbial production remains limited by pathway bottlenecks and challenges in engineering key biosynthetic enzymes. Here, we devel...
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Incorporation of single-neuron projectome-based connectivity motifs enhances the cortex-specific performance of artificial neural networks

bioRxiv Jun 17, 2026
The organizational principles of natural neural networks could inspire the new architecture design of artificial neural networks (ANNs). Analysis of single-neuron connectomes of mouse brains revealed distinct profiles of three-node connectivity motif...
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Identification of Direct and Network-Mediated Activation of Retinal Ganglion Cells from Visually Evoked Potentials Using Machine Learning

bioRxiv Jun 17, 2026
Objective. To preserve the encoding of visual information in prosthetic vision as close to natural as possible, subretinal photovoltaic implants, which replace the lost photoreceptors, strive to stimulate the second-order retinal neurons, the bipolar...
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MetaHarmonizer: robust biomedical metadata harmonization and a contamination control for inflated LLM performance on public benchmarks

bioRxiv Jun 17, 2026
Public biomedical repositories hold substantial reuse potential, but inconsistent metadata routinely blocks integration across studies. Recent LLM-based harmonization approaches address scale but suffer from non-determinism, hallucinated ontology ter...
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A Structural Principle for Macroscopic Neural Dynamics Correlations

bioRxiv Jun 17, 2026
A central question in neuroscience is how the brain's structural connectivity gives rise to its emergent, correlated dynamics. These large-scale dynamical correlations underlie functional networks that support cognitive functions. Here, we identify c...
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DesignMaster: A Multi-Conditional Diffusion Framework for Rational PROTAC Design

bioRxiv Jun 17, 2026
Motivation: Proteolysis-targeting chimeras (PROTACs) enable targeted protein degradation through ternary complex formation with E3 ubiquitin ligase. However, the rational design of PROTACs remains highly challenging due to limited structure-activity ...
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DNA-binding specificity recognition from predicted homologous protein-DNA structures

bioRxiv Jun 17, 2026
Predicting protein DNA-binding specificity is essential for understanding gene regulation and disease mechanisms. Existing deep learning methods typically infer specificity from a single protein-DNA complex structure, which limits their ability to ca...
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Identifying Modulators of Cellular Responses by Heterogeneity-sequencing

bioRxiv Jun 16, 2026
The response of individual cells to drug treatment, virus infections or other molecular stimuli is highly heterogeneous and depends on the cell's initial state. Library preparation for single-cell transcriptomics is destructive, precluding a direct c...
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