AIMC Journal:
bioRxiv

Showing 1101 to 1110 of 4938 articles

DNA Compression with Genomic Language Models: Tokenization, Benchmarking, and an Information-Content Map

bioRxiv Jun 12, 2026
Lossless compression and probabilistic sequence modeling are two faces of the same coin: a model that assigns high probability to a sequence can encode it in few bits via arithmetic coding. We exploit this duality to evaluate genomic language models ...
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Deciphering cross-omics complexity of tissues via diagonal integration of unpaired spatial multi-omics data

bioRxiv Jun 12, 2026
Recent spatial multi-omics technologies enable the simultaneous in situ profiling of multiple omics modalities on the same tissue section; however, they face challenges in experimental complexity and high costs. This technical limitation can be circu...
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LizardMorph: A generalizable machine learning framework for automated anatomical landmark detection in digital images

bioRxiv Jun 12, 2026
Morphological measurements underpin a wide range of ecological and evolutionary research, yet the manual landmarking workflows on which most morphometric studies depend remain a persistent bottleneck that limits both the pace and scale of biological ...
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Leveraging genome-wide association studies and genomic prediction for distinctness, uniformity, and stability (DUS) testing in maize

bioRxiv Jun 12, 2026
Testing for distinctness, uniformity, and stability (DUS) is a requirement for plant variety registration and based on phenotypic traits, which is time-consuming and sensitive to envi-ronmental variation. Advances in genomics allow to complement DUS ...
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CAREPath: Semantic Context-Aware Reasoning Paths with Mechanism-Augmented Embeddings for Drug Repurposing

bioRxiv Jun 12, 2026
Biomedical knowledge graphs (BKGs) that include drugs, genes, and diseases support drug repurposing by connecting drugs to diseases through gene-mediated multi-hop paths, thereby enabling mechanism-of-action reasoning. However, deeper traversal does ...
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Positive Interpretation of Emotional Ambiguity Across Development: LC-dlPFC Circuitry

bioRxiv Jun 12, 2026
Emotionally ambiguous facial expressions provide a tractable model for studying how uncertain affective information is resolved into categorical judgments. Here we tested whether developmental differences in this process are reflected in locus coerul...
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LizardLens: A Two-Stage Deep Learning Pipeline for Detecting and Classifying Similar Species in Visually Complex Environments

bioRxiv Jun 12, 2026
Community science platforms like iNaturalist generate unprecedented volumes of biodiversity data, but their scientific utility depends critically on accurate species identification; a persistent challenge when contributors often lack taxonomic expert...
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A Graph-based QSAR Modeling Pipeline for Predicting In vitro PubChem Assays and In vivo Human Hepatotoxicity: Mechanistic Analysis of Caspase-3/7 Activation

bioRxiv Jun 12, 2026
Background: Caspase-3 and -7 are key effector caspases in the apoptotic pathway, a form of programmed cell death, and their activities serve as a well-established biomarker for evaluating environmental chemical toxicity and informing chemical risk as...
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Video-based eye movements are linked to cortical and pupil-based arousal in human sleep

bioRxiv Jun 12, 2026
Study Objectives To quantify high-resolution video-based eye kinematics across sleep macro- and microstructure and determine their coupling with pupil-based and cortical arousal markers. Methods We recorded polysomnography and utilized infrared video...
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MAHLER: Integrating Metadynamics and Inverse Folding to Predict Antibody-Antigen Kinetics

bioRxiv Jun 12, 2026
Binding kinetics are crucial for antibody function, shaping pharmacokinetics and in vivo efficacy beyond what equilibrium affinity captures. We present "Metadynamics-Anchored Hybrid Learning for Engineering off-Rates (MAHLER)", a fully open-source ma...
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