AIMC Journal:
bioRxiv

Showing 1121 to 1130 of 4938 articles

A multi-agent system for spine MRI report generation from multi-sequence imaging

bioRxiv Jun 11, 2026
Spinal pathology is a leading cause of pain and disability worldwide. Spine magnetic resonance imaging (MRI) is central to clinical evaluation, yet its interpretation remains complex and time-consuming, requiring integration of information across mul...
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OCOO-T : A SIMPLE AND SCALABLE VIRTUAL CELL MODEL FOR TRANSCRIPTIONAL PERTURBATION RESPONSE PREDICTION

bioRxiv Jun 11, 2026
Predicting single-cell transcriptional responses to genetic, chemical and cytokine perturbations is a fundamental challenge in computational biology and AI Virtual Cell (AIVC) modeling, with direct implications for drug discovery and the elucidation ...
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STITCH links cellular morphology and gene expression in spatial transcriptomics

bioRxiv Jun 11, 2026
In situ spatial (ISS) sequencing can uncover co-variation between cellular morphology and gene expression in vivo. However, a principled and interpretable mathematical representation of morphology has not yet been applied in this context. In particul...
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Improving splice site usage prediction with SPLAIRE

bioRxiv Jun 11, 2026
Alternative splicing, the mechanism by which intronic sequences are excised from pre-mRNAs to produce mature mRNA, affects >95% of human protein-coding genes and is a major driver of human disease states. The spliceosome, a protein-RNA complex respon...
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DigiMus: a connectome-informed spiking framework for multi-region mouse neural-behavior modeling

bioRxiv Jun 11, 2026
Computational models are increasingly used to relate mouse brain structure, neural activity and behavior, but most models still learn from task data with limited constraints from biological circuit organization. Here we present DigiMus, a connectome-...
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Single-camera, calibration-free gaze estimation using corneal reflections

bioRxiv Jun 11, 2026
Background. Mice make substantial eye movements during head-fixed visual stimulation, and uncorrected gaze shifts corrupt receptive field measurements and confound stimulus-response relationships. Corneal-reflection video oculography in rodents has p...
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DeePEn - A Depth sensitive benchmark for Protein Engineering

bioRxiv Jun 11, 2026
Recent progress in modeling techniques and high-throughput screening has significantly enhanced the accessibility of protein engineering. Nevertheless, further progress gets hindered by the lack of robust benchmarks that capture the practical challen...
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Attenuation of value-to-evidence translation drives biased decision making in anxiety and depression

bioRxiv Jun 11, 2026
Anxiety and depression are globally prevalent conditions associated with maladaptive decision making. However, whether affective symptoms primarily amplify threat avoidance or dampen motivational drive remains debated, and behavioural studies yield i...
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Explainable AI identifies H3K18ac as a new marker of active enhancers

bioRxiv Jun 11, 2026
Enhancers are non-coding regions of DNA that regulate gene transcription, yet the mechanisms underlying enhancer activity remain incompletely understood. Despite extensive experimental and computational efforts, we still lack accurate enhancer maps i...
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A Deep Hypergraph Learning Model for Predicting Antimicrobial Combination Effects Across Bacterial Targets

bioRxiv Jun 11, 2026
Antimicrobial resistance (AMR) creates an urgent need for efficient strategies to identify effective antibacterial combinations. Combination therapy, including antimicrobial peptides (AMPs) paired with conventional antibiotics, is a promising approac...
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