AIMC Journal:
bioRxiv

Showing 1321 to 1330 of 4956 articles

Study on Liver Sinusoidal Endothelial Cell Fenestrations Based on Cellular Omics-Structure Integration Technology and Its Application in Metabolic Diseases

bioRxiv May 28, 2026
This study developed a new Cellular Omics-Structural Integration (COSI) technology platform to address the limitation of traditional technologies in simultaneously obtaining gene expression profiles and super-resolution cellular structural informatio...
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DORA: a dose-response autoencoder for interpretable transcriptome-to-viability prediction

bioRxiv May 28, 2026
Predicting the effect of drugs on cell viability is a central challenge in drug discovery. Artificial intelligence holds the promise to considerably accelerate this process by leveraging rich cellular data such as transcriptomics. Current models focu...
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Data Representation Bias and Conditional Distribution Shift Drive Predictive Performance Disparities in Multi-Population Machine Learning

bioRxiv May 28, 2026
Machine learning frequently encounters challenges when applied to population-stratified datasets, where data representation bias and data distribution shifts substantially impact model performance and generalizability across different population grou...
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Intact early visual representations, not phosphene-adapted features, account for human perceptual behavior with retinal prostheses

bioRxiv May 28, 2026
Efforts to restore vision via neural implants have outpaced the ability to predict what users will perceive, leaving patients and clinicians without reliable tools for surgical planning or device selection. To bridge this critical gap, we introduce a...
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Sequence-Based Prioritization of Promoter Regulatory Variants in Colorectal Cancer Using a DNA Foundation Model

bioRxiv May 28, 2026
Noncoding regulatory variants contribute to colorectal cancer (CRC) susceptibility, yet their functional interpretation remains difficult.This is mainly attributed to regulatory effects being context-dependent and most noncoding regions lack reliable...
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gTranslate: rapid and accurate translation table prediction for prokaryotic genomes

bioRxiv May 28, 2026
Background: Bioinformatic tools often require the prediction of protein-coding genes to make inferences about prokaryotic genomes. Typically, the genetic code used for translating genes to proteins must be specified by the user based on the taxonomic...
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UcTCRp: a TCRβ-based framework for quantitative MAIT- and iNKT-associated repertoire-state profiling

bioRxiv May 28, 2026
MAIT and iNKT cells are conventionally identified using invariant or semi-invariant TCR chains, antigen-loaded tetramers, or transcriptomic phenotypes. These requirements limit their detection in public and clinical immune-repertoire datasets that co...
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Mapping Genetic Risk Associations to Cellular Contexts via Deep Learning and Biological Ontologies

bioRxiv May 28, 2026
Translating genome-wide association studies (GWAS) signals into trait-relevant cellular contexts remains challenging due to the complexity of the genomic regulatory code and linkage disequilibrium among associated variants. We present a novel computa...
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MedMisBench: Measuring Epistemic Resilience of LLMs Under Misleading Medical Context

bioRxiv May 28, 2026
Large language models (LLMs) now reach expert-level scores on medical licensing exams, encouraging the assumption that high scores imply safe medical judgment while patients increasingly use them for health advice. We show this assumption is fragile:...
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A New Hybrid Method for Brain Tumor Detection Based on Deep Learning

bioRxiv May 28, 2026
Brain tumor detection using Magnetic Resonance Imaging (MRI) remains a challenging task due to tumor hetero-geneity and imaging variability. This paper presents a novel hybrid Deep Convolutional Neural Network Whale Optimization Algorithm (DCNN,WOA) ...
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