AIMC Journal:
bioRxiv

Showing 1351 to 1360 of 4956 articles

Distinct afferent signatures onto anterior and posterior VMHvl subdomains and their progesterone receptor-expressing neurons

bioRxiv May 27, 2026
Female sexual behavior is fundamentally coupled to reproductive state, requiring the dynamic and coordinated regulation of sexual receptivity and rejection across the estrous cycle. In mice, these opposing behaviors are controlled by distinct neurona...
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Affinity Fine-Tuning of Boltz-2: An Open Framework for Protein-Ligand Potency Prediction in Drug Discovery

bioRxiv May 27, 2026
Boltz-2 has enabled accurate binding affinity prediction by leveraging co-folded protein-ligand structures, but the absence of a public training recipe has limited its use in active drug discovery projects, where new experimental measurements and con...
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Signal, Bounds, and Baselines: Principles for Evaluating Virtual Cell Perturbation Models

bioRxiv May 27, 2026
Foundation models and deep learning systems are increasingly proposed as core components of "virtual cells" capable of forecasting transcriptomic responses to unseen perturbations. Yet rigorous evaluation of perturbation prediction in high-dimensiona...
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OryzaG3: A Single-species Genomic Foundation Model Pretrained on Rice Pangenome

bioRxiv May 26, 2026
While multi-species genomic language models have advanced biological representation learning, high-quality, single-species foundation models for crops remain scarce. Leveraging recently expanded rice pangenome resources, we introduce OryzaG3, a speci...
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Automated sleep scoring in hibernating and non-hibernating American black bears

bioRxiv May 26, 2026
Hibernating bears show remarkable metabolic suppression. Their decline in core body temperature (Tb) is moderate(from 38{degrees}C to 30-35{degrees}C), but their metabolism declines as much as 75%. To understand the role of sleep in this hypometaboli...
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IID-KG: An ontology-aligned literature-derived knowledge graph for infectious and immune-mediated diseases

bioRxiv May 26, 2026
Infectious and immune-mediated diseases (IIDs) represent a broad and rapidly expanding biomedical literature domain in which scalable evidence extraction, disease ontology refinement, and interpretable knowledge integration are essential for biomedic...
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Application of Computer Vision Tools to Maize Genomic Data for Trait Prediction and Gene Discovery

bioRxiv May 26, 2026
Artificial intelligence and machine learning for computer vision (CV) and image recognition is a rapidly evolving field with multiple potential applications in plant genomics. While CV has been widely adopted by the research community for plant pheno...
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Pathogen-specific antimicrobial activity prediction with biological large language model-based methods

bioRxiv May 26, 2026
Driven by the rise of antimicrobial resistance, antimicrobial peptides (AMPs) have emerged as promising therapeutics capable of targeting multidrug-resistant pathogens. Because identifying AMPs and their specific targets requires costly and labor-int...
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Random network structure stabilizes neural manifolds

bioRxiv May 26, 2026
Neuronal activity patterns change continuously over days and weeks, a phenomenon known as representational drift. Despite this, the geometric structure of population representations, namely the pairwise similarities between stimulus-evoked activity p...
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Evaluation of Active Learning Selection Strategies and Characterization of Informative Sequences for Sequence-to-Expression Models

bioRxiv May 26, 2026
DNA sequence-to-expression models have advanced rapidly, yet they still generalize poorly beyond their training distribution, limiting their use for tasks such as variant effect prediction. Active learning has improved data efficiency across many mac...
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