AIMC Journal:
bioRxiv

Showing 1381 to 1390 of 4956 articles

Carbon: Decoding the Language of Life

bioRxiv May 25, 2026
Genomic foundation models have emerged alongside the rapid progress of large language models, offering a promising framework for learning general-purpose sequence priors for DNA understanding, generation, and design. This connection to LLMs creates a...
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Chromatin accessibility of primary cancers informs regional mutagenesis in metastases through multi-scale deep learning

bioRxiv May 25, 2026
Tissue-specific chromatin states shape regional mutation density in primary tumors, but whether this relationship persists in metastases is unclear. We integrated whole-genome sequencing data from 2,507 metastatic tumors across six cancer types with ...
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SpatialClaw: A Memory-Augmented Autonomous Ecosystem for Spatial Omics Analysis

bioRxiv May 25, 2026
While the expansion of spatial omics has revolutionized our ability to dissect tissue architecture, the accumulation of incompatible computational methods has heavily fragmented end-to-end analysis, rendering complex workflows irreproducible. Generic...
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Genomic Diagnostics for Drug-Resistant Mycobacterium tuberculosis: Computational Prediction of Antimicrobial Resistance

bioRxiv May 25, 2026
Tuberculosis remains a leading cause of infectious disease mortality, and the continued emergence of drug-resistant Mycobacterium tuberculosis strains threatens the effectiveness of standard treatment regimens. Culture-based antibiotic susceptibility...
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Biomineralized Surface-Enhanced Raman Scattering Nanotags Encode Biomolecular Identity into Machine Learning-Resolvable Plasmonic Fingerprints

bioRxiv May 25, 2026
Surface-enhanced Raman scattering (SERS) nanotags provide highly sensitive platforms for in vitro diagnostics but often require complex, disease-specific customization that limits clinical translation. Biomineralization, in which biomolecules mediate...
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Interpreting the WaveSeekerNet model to reveal the evolution and biology of influenza A virus

bioRxiv May 25, 2026
Background Influenza A virus (IAV) is a major public health burden, causing seasonal epidemics and occasional pandemics. Its transmission from avian species to mammals and subsequent spread requires adaptive changes in the viral genome. Understanding...
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Spatio-temporal machine learning for multi-horizon prediction of bluetongue outbreaks

bioRxiv May 24, 2026
Reliable early warning of infectious disease outbreaks remains a major challenge for surveillance systems, particularly for vector-borne pathogens whose transmission depends on interactions among hosts, vectors, and climate-sensitive environmental co...
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Genos-m: a foundation model for human-associated microbial genomes

bioRxiv May 24, 2026
Human-associated microbial genomes encode extensive strain-level diversity and niche-specific gene repertoires that are critical to host health. However, these complex sequence features remain difficult to capture using general-purpose DNA foundation...
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A machine learning framework for interpreting phylogenetic tree patterns in interkingdom horizontal gene transfer

bioRxiv May 24, 2026
Horizontal gene transfer (HGT), the movement of genetic material between unrelated organisms, is widely recognized as an important driver of genome evolution in bacteria. In eukaryotes, however, the evolutionary impact of HGT remains debated. The ide...
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From Functional Architecture to Organizing Principles of Neuronal Ensembles in Mouse Area V1

bioRxiv May 24, 2026
While single neuron responses in mouse V1 are well characterized, less is known about how functional ensembles--groups of neurons that co-activate more frequently than expected by chance--emerge as computational units within laminar V1 circuits. Even...
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