AIMC Journal:
bioRxiv

Showing 1561 to 1570 of 4956 articles

Genomic Foundation Models Reveal Chromatin-Domain-Scale Transposable Element Impacts on Rice Genome Architecture

bioRxiv May 13, 2026
Alignment-based detection of transposable element (TE) insertion polymorphisms suffers from reference bias and multi-mapping errors in repetitive genomic regions, creating a fundamental validation bottleneck for population-scale structural variant ca...
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Tuning into the city soundscape: Optimizing Convolutional Neural Networks for avian acoustic identification in the neotropics and evaluating their performance against established monitoring approaches.

bioRxiv May 13, 2026
Convolutional Neural Networks (CNNs) have become increasingly prominent in biodiversity monitoring due to their strong performance in accurately detecting species from sound recordings, overcoming some limitations of traditional methods such as point...
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Kinome profiling allows examination and prediction of kinase inhibitor cardiotoxicity

bioRxiv May 12, 2026
Background: Despite improved cancer outcomes with kinase inhibitors (KIs), their cardiotoxicity remains a significant clinical challenge. Current approaches to predict and prevent KI-induced cardiac adverse events (CAEs) are limited by an incomplete ...
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CardioSafe: Multi-task prediction of cardiac ion channel activity with reverse-leak audited benchmarking

bioRxiv May 12, 2026
Drug-induced inhibition of the hERG potassium channel is the leading cause of cardiac safety-related drug attrition, but the Comprehensive in Vitro Proarrhythmia Assay (CiPA) framework requires activity data on multiple cardiac ion channels to assess...
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An fMRI dataset of verbalized spontaneous thought with annotated transcripts and self-report trait measures

bioRxiv May 12, 2026
Spontaneous thought is pervasive in everyday human cognition, yet datasets capturing its neural dynamics under minimally interrupted conditions remain limited. The current dataset was acquired from a think-aloud functional MRI experiment in which 118...
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ConvergeCELL: An end-to-end platform from patient transcriptomics to therapeutic hypotheses

bioRxiv May 12, 2026
Translating transcriptomic data into therapeutic hypotheses remains fragmented and labor-intensive. Here we present ConvergeCELL, a platform combining a patient representation model trained on over 20 million cells across 4,479 patients, an interpret...
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The illusion of interpretability in biologically informed neural networks

bioRxiv May 12, 2026
Biologically informed neural networks (BINNs), also known as visible neural networks (VNNs), are widely adopted in omics because their architectures mirror known biological structures, such as gene-to-pathway relationships, and are therefore often as...
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Structural brain networks shape individual-level progression of brain atrophy after stroke

bioRxiv May 12, 2026
Stroke starts as a focal vascular lesion, but its structural consequences often extend beyond the lesion site, resulting in distributed brain atrophy whose organizing principles remain unclear. Here, using longitudinal MRI data from two stroke cohort...
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Integrative Genomic, Single-Cell, and Functional Profiling of the CD48-CD244 Axis and NK-Cell Dysfunction in Multiple Myeloma

bioRxiv May 12, 2026
Multiple myeloma (MM) orchestrates immune evasion by subverting natural killer (NK) cell function. CD48, one of the most abundant NK-ligands on MM cells, paradoxically enhances NK-cell activation yet is associated with high-risk cytogenetics and poor...
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Machine Learning Analysis to Define Cell Lineage in Leiomyosarcoma

bioRxiv May 12, 2026
Introduction Cellular differentiation and lineage commitment are known to be associated with differences in DNA methylation. Leiomyosarcoma (LMS) is a tumor thought to originate from smooth muscle cells in the walls of vessels in the soft tissue (STL...
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