AIMC Journal:
bioRxiv

Showing 1571 to 1580 of 4956 articles

Mechanisms Matter: Transportability of Cellular Perturbation Effects

bioRxiv May 12, 2026
Predicting cellular responses to genetic or chemical perturbations across biological contexts is central to drug development and disease understanding.Despite increases in data and model scale, deep learning models have not consistently outperformed ...
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Systematic toxicological study of PFOS/PFOA co-exposure driving prostate cancer: Core target identification, TME immune remodeling, and combination drug prediction

bioRxiv May 12, 2026
Background: Per- and polyfluoroalkyl substances (PFAS), particularly perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), are persistent organic pollutants ubiquitous in the environment. Epidemiological evidence has closely linked them...
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Virtual screening and zebrafish phenotype-based evaluation argues against repurposing 4-phenylbutyrate for STXBP1-relateddisorders

bioRxiv May 12, 2026
Syntaxin-binding protein 1 (STXBP1) mutations lead to severe epilepsy, intellectual disability, developmental delay, and movement disorder. Effective treatments for these conditions do not exist. Recent studies in Munc18-1 (STXBP1) C.elegans models d...
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Serum proteomic atlas reveals distinct molecular signatures of lupus nephritis activity, chronicity, and treatment response

bioRxiv May 12, 2026
Lupus nephritis (LN), a severe manifestation of systemic lupus erythematosus (SLE), features heterogeneous renal pathology and reliance on invasive biopsies for diagnosis, prognosis, and treatment selection. Current peripheral clinical markers inadeq...
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Unifying the Electron Microscopy Multiverse through a Large-scale Foundation Model

bioRxiv May 12, 2026
Accurate analysis of electron microscopy (EM) images is essential for exploring nanoscale biological structures, yet data heterogeneity and fragmented workflows hinder scalable insights. Pretrained on large, diverse datasets, image foundation models ...
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Predicting curvature evolution on biological surfaces from clinical imaging-derived area dilation: a closed-form interpretable framework

bioRxiv May 12, 2026
Curvature evolution on a deforming surface is governed by the full change in the surface metric, but on biological surfaces captured by serial three-dimensional imaging, only the local area change is observable. The loss of the shear component leaves...
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Culsma: A Formal Language for Laboratory Protocols

bioRxiv May 12, 2026
The application of artificial intelligence to biomedical research increasingly depends on iterative cycles in which AI systems analyze experimental data, propose follow-up conditions, and drive automated execution at scale, a paradigm central to Bio-...
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Dual-view Guided Context-aware Network for Automated Bone Lesion Segmentation and Quantification in Whole-body SPECT

bioRxiv May 12, 2026
Whole-body SPECT bone scintigraphy reflects skeletal metabolic activity throughout the body and plays an indispensable role in the screening, treatment evaluation, and prognostic assessment of bone metastases in tumors. However, the automatic detecti...
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Transferable Transcriptional Topic Modeling Traces Medulloblastoma Subtypes to Distinct Cerebellar Developmental States

bioRxiv May 12, 2026
Single-cell transcriptomics transformed our understanding of cellular heterogeneity, yet cross-dataset comparison remains fundamentally limited by batch effects, technology differences, and inconsistent annotation frameworks. These challenges have im...
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A CBF-SA module links wound-induced evaporative cooling to tissue repair in plants

bioRxiv May 12, 2026
Repairing damaged tissues is essential for the survival of all organisms. In plants, tissue injury rapidly triggers defense and repair programs. However, the molecular mechanisms linking early injury cue to the later stages of wound repair remain unc...
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