AIMC Journal:
bioRxiv

Showing 1691 to 1700 of 4956 articles

Polysemanticity in human hippocampal neurons

bioRxiv May 4, 2026
To comprehend language, the brain must navigate a high-dimensional semantic landscape while seamlessly contextualizing meaning. Inspired by recent advances in the mechanistic interpretability of large language models (LLMs), we hypothesized that the ...
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Whole-body 3D kinematics of freely behaving Drosophila

bioRxiv May 4, 2026
Understanding how nervous systems generate coordinated movement requires precise measurement of body kinematics during natural behavior. The fruit fly, Drosophila, is a model organism with sophisticated behavior and well-studied neural circuits, but ...
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DoFormer: Causal Transformer for Gene Perturbation

bioRxiv May 4, 2026
Learning causal gene regulatory mechanisms from single-cell data, and thereby predicting the effects of unseen perturbations, remains challenging. Observational RNA-seq data alone is insufficient for causal modeling, whereas perturbational data is es...
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Do Larger Models Really Win in Drug Discovery?A Benchmark Assessment of Model Scaling in AI-Driven Molecular Property and Activity Prediction

bioRxiv May 4, 2026
The rapid growth of molecular foundation models and general-purpose large language models has encouraged a scale-centric view of artificial intelligence in drug discovery, in which larger pretrained models are expected to supersede compact cheminform...
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A generative reference grammar of healthy TCR repertoires reveals cancer-associated immune remodeling

bioRxiv May 4, 2026
T-cell receptor (TCR) repertoires encode the organization of adaptive immunity and its reshaping by cancer and therapy, but disentangling treatment-associated structure from V(D)J recombination constraints remains challenging. We present CRAFT (Cance...
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An unsupervised framework for comparing SARS-CoV-2 protein sequences using LLMs

bioRxiv May 3, 2026
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic led to 700 million infections and 7 million deaths worldwide. While studying these viruses, scientists developed a large amount of sequencing data that was made available to re...
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Molecular insights into protein disulfide isomerase antagonism by punicalagin

bioRxiv May 3, 2026
Punicalagin, an ellagic acid polyphenol from pomegranate, has been proposed as an antagonist of protein disulfide isomerase (PDI) and endoplasmic reticulum resident protein 57 (ERp57), thiol oxidoreductases that regulate protein folding and extracell...
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Agentic systems are adept at solving well-scoped, verifiable problems in computational biology

bioRxiv May 3, 2026
We introduce CompBioBench, a benchmark of 100 diverse tasks for evaluating agentic systems in computational biology. Unlike mathematics and programming, which more readily admit systematic verification, biological data are inherently noisy and open t...
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A Tissue Microenvironment Analogous to Certain Tumor Microenvironments Facilitates HIV Persistence

bioRxiv May 2, 2026
The HIV reservoir that establishes early upon infection and persists in tissues remains the primary barrier to a functional cure. While progress has been made to study the reservoir in blood compartments and specific cell types, knowledge gaps remain...
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Knowledge Inclusive Machine Learning for Disease Gene Prioritisation

bioRxiv May 2, 2026
The predictive performance of machine learning models depends on the context available to them. In disease gene prioritisation, this context comprises two forms: specific context from sample-level experimental data, such as gene expression and protei...
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