AIMC Journal:
bioRxiv

Showing 1761 to 1770 of 4956 articles

UshEffect-3D: Structure-informed Classification of USH2A Missense Variants for Inherited Retinal Disease

bioRxiv Apr 27, 2026
Variants of uncertain significance (VUS) in USH2A represent a critical interpretive challenge in inherited retinal disease, with over 70% of ClinVar submissions for this gene currently unresolved. We developed UshEffect-3D, a gene-specific, structure...
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Generative design of sequence specific DNA binding proteins

bioRxiv Apr 27, 2026
De novo protein design has advanced rapidly in recent years, yet the programmable recognition of specific DNA sequences remains a longstanding challenge. Here we describe a deep learning based approach for designing sequence selective DNA binding pro...
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Predictive pursuit emerges in high-dimensional recurrent neural networks

bioRxiv Apr 27, 2026
Tracking dynamic moving objects in the external world is ethologically important for many organisms. Recent experiments have examined neural dynamics supporting such behaviors by employing visually-guided pursuit in freely moving rodents, yet computa...
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Integrative Clinical-Molecular Modeling Identifies LRRN4CL as a Determinant of Structural and Functional Myocardial Improvement

bioRxiv Apr 26, 2026
Background: Mechanical ventricular unloading and systemic circulatory support with left ventricular assist devices (LVADs) enable myocardial recovery in a subset of advanced heart failure (HF) patients, but predictors and mechanisms of recovery are n...
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A Deep Learning-Based Scoring Framework for Large-Scale Multi-Donor Cardiotoxicity Screening

bioRxiv Apr 26, 2026
Cardiotoxicity remains a major cause of drug attrition and post-market withdrawal, yet the vast majority of environmental chemicals to which humans may be exposed remain uncharacterized for cardiotoxicity risk. Human induced pluripotent stem cell (hi...
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A Systematic Approach Toward Implementing Machine Learning Techniques to Analyze Gut Microbiome Data

bioRxiv Apr 26, 2026
This study investigates the relationship between the gut microbiota and specific diseases. Data was collected from the Human Gut Microbiome Atlas, which examines regional variations across 20 countries on five continents, categorizing microbial speci...
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Cross-Species Adaptation of RETFound for Rodent OCT Age Estimation Reveals Strong CNN Baselines in Data-Scarce Space Biology

bioRxiv Apr 26, 2026
Space-biology imaging studies are often constrained by severe data scarcity, limiting the development of robust machine-learning biomarkers. Rodent spaceflight and space-analog datasets provide an important preclinical setting for testing transfer-le...
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GlioVision: A Multi-Modal MRI Framework for Non-Invasive Glioma Molecular Biomarkers Prediction

bioRxiv Apr 26, 2026
Gliomas are aggressive primary brain tumors that necessitate critical molecular biomarker predictions for optimal clinical decision-making. Traditional assessment relies on surgical tumor specimens analysis, which carries procedural risks and samplin...
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Decoding the phenomenology of spontaneous thought using large language-model ratings on verbal retrospective free reports

bioRxiv Apr 26, 2026
Spontaneous thoughts constitute most of everyday inner experience, yet long-standing methodological challenges obscure a thorough exploration of their content and neurophysiological underpinnings. Traditional approaches relying on thought probes impo...
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Multi-Modal Deep Learning Integrates Spatial Topologies and Sequential Motifs to Identify Class I HDAC Inhibitors as Pan-Cancer Therapeutics

bioRxiv Apr 25, 2026
The molecular characterization of human solid growths has introduced immense genomic complexity and intra-tumoral diversification. Converting these detailed, multi-omic profiles right into workable, broad-spectrum therapeutics continues to be an awes...
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