AIMC Journal:
bioRxiv

Showing 1791 to 1800 of 4956 articles

Graph Neural Networks (GNNs) for Protein-Ligand Interaction Prediction

bioRxiv Apr 24, 2026
Predicting protein-ligand interactions in the modern drug discovery has revolved from the involvement of artificial intelligence and structural bioinformatics using Graph Neural Networks (GNNs). The limited explainability of GNN models presents an im...
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Predictive Cellular Signatures from Live Human Motor Neurons Distinguish TDP-43 ALS and Enable ALS Subtype Stratification

bioRxiv Apr 24, 2026
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the progressive, rapid deterioration of motor neurons (MNs). Rare mutations in a handful of genes are sufficient to cause ALS; however, 90% of ALS cases are no...
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A Generative AI Framework to Predict Cardiomyocyte Contraction Function from Single Static Images.

bioRxiv Apr 24, 2026
Understanding how cardiomyocyte structure governs contractile function is fundamental to cardiac biology and disease modeling, yet current approaches rely on time resolved imaging and computationally intensive analysis. Here, we present a generative ...
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Image-grounded encoding models reveal distinct temporal profiles of naturalistic object and scene processing in the human brain

bioRxiv Apr 24, 2026
The human brain processes large amounts of complex visual information in order to effectively interact with its environment. It is well established that our visual system has specialized regions to process incoming information efficiently, such as sc...
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Learning temporal structure engages hippocampus and guides value-based behaviour

bioRxiv Apr 24, 2026
The ability to learn and exploit structured relationships between events is fundamental to adaptive behaviour and episodic-like memory, yet the neural mechanisms that support such learning remain poorly understood. Progress has been limited by the di...
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Modular organization and selective motifs in the insula provide structural priors for efficient learning

bioRxiv Apr 23, 2026
The insular cortex (IC) integrates diverse sensory and interoceptive signals to support emotional and cognitive functions, exhibiting topologically functional distinctions. Although long-range pathways of the IC have been extensively mapped, the cont...
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Entrenchment of germline amino-acid differences in antibody affinity maturation

bioRxiv Apr 23, 2026
Entrenchment - epistasis that locks in amino acid differences between homologous proteins, so each disfavors substitutions toward the other's state - has been demonstrated along individual protein lineages over deep evolutionary time. Antibodies offe...
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Spectral envelopes of facial movements predict intention, cortical representations, and neural prosthetic control

bioRxiv Apr 23, 2026
Animals, including humans, use coordinated facial movements to sample the environment, ingest nutrients, and communicate. Rodents, in particular, produce rhythmic facial movements during spontaneous behavior and cognitive tasks. Measuring these movem...
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GeneBench: Assessing AI Agents for Multi-Stage Inference Problems in Genomics and Quantitative Biology

bioRxiv Apr 23, 2026
We introduce GeneBench, a benchmark for AI agents on realistic multi-stage scientific data analysis in genetics and quantitative biology. Existing biology benchmarks mostly measure knowledge retrieval, execution of routine pipelines, or a single anal...
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Aligned recordings of neural spiking activity and licking behavior in thirsty mice

bioRxiv Apr 23, 2026
Electrophysiological data, which serve as a biological signal that bridges neural activity and behavioral tasks, provide an innovative approach to neuroscience research. In this study, we constructed a dataset that contains over 2000 neurons across 1...
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