AIMC Journal:
bioRxiv

Showing 1821 to 1830 of 4956 articles

Mass cytometry data integration methods reveal rural-urban gradient of immune profiles across geography

bioRxiv Apr 17, 2026
The human immune system strongly varies across populations and is shaped by a wide range of host and environmental factors. As such, a rural compared to urban lifestyle has previously been associated with baseline differences in immune profiles, whic...
View on bioRxiv DOI

Informational and methodological differences in regional structure-function coupling in modeling approaches

bioRxiv Apr 17, 2026
Structural connectivity in the human brain constrains functional connectivity, which in turn reshapes structural connectivity, resulting in complex coupling relationships. Numerous approaches exist for quantifying structure-function coupling, and dif...
View on bioRxiv DOI

Integrating glycosylation in de novo protein design with ReGlyco Binder Design Filter

bioRxiv Apr 17, 2026
Artificial Intelligence (AI)-based methods for 3D protein structure prediction are revolutionising structural biology, providing novel templates for experimental data refinement and an on demand 3D perspective on any molecular architecture and protei...
View on bioRxiv DOI

The Euler Characteristic Transform Enables Classification of Complex Plant Shapes and Prediction of Leaf Venation from Blade Geometry

bioRxiv Apr 16, 2026
Rationale: Quantifying and predicting plant morphology is central to understanding development and evolution, yet many plant forms lack homologous features required for traditional morphometrics. We apply the Euler Characteristic Transform (ECT), an ...
View on bioRxiv DOI

Neural mechanism of postural sway-related beta-band oscillations: a cortico-basal ganglia-thalamic network model of intermittent control

bioRxiv Apr 16, 2026
Recent EEG studies of human quiet stance have identified beta-band event-related desynchronization (beta-ERD) and synchronization (beta-ERS; post-movement beta rebound) during the micro-fall and micro-recovery phases of postural sway, respectively. T...
View on bioRxiv DOI

Generative design of intrinsically disordered proteins based on conditioned protein language models: Data is the limit

bioRxiv Apr 16, 2026
Intrinsically disordered proteins and regions (IDRs) are central to a multitude of biological processes. Despite extensive studies of their structural and physicochemical properties, the rational design of IDRs with defined conformational behavior re...
View on bioRxiv DOI

Multiscale transcriptomic organization of the human brain with DigitalBrain

bioRxiv Apr 16, 2026
The human brain varies across anatomical regions, cell types, development, ageing and disease states, yet existing single-cell transcriptomic resources remain fragmented and difficult to integrate into a unified biological model. Here we present Digi...
View on bioRxiv DOI

Sampling antibody conformational ensembles withABodyBuilder4-STEROIDS

bioRxiv Apr 16, 2026
Conformational flexibility is fundamental to the function of many proteins and in the case of antibodies can impact key properties such as affinity and specificity. While it is possible to predict single, static protein structures with high accuracy,...
View on bioRxiv DOI

Learning to select computations in recurrent neural circuits

bioRxiv Apr 16, 2026
Two hallmarks of biological computation are its flexibility and efficiency. These features are often attributed to cognitive control processes that balance external utility against computational cost. However, how the brain could implement such adapt...
View on bioRxiv DOI

Reinforcement learning for closed-loop optimisation of spatiotemporal stimulation in patterned neuronal networks

bioRxiv Apr 16, 2026
Understanding how neuronal circuits transform inputs into outputs requires systematic perturbation under controlled conditions. In vitro neuronal networks can be cultured on microelectrode arrays (MEAs) that allow stimulation and recording, and micro...
View on bioRxiv DOI
Popular Topics
Popular Journals