AIMC Journal:
bioRxiv

Showing 1831 to 1840 of 4956 articles

Latent neural network representations of the brain reflect broad-scale adolescent phenotypic variation

bioRxiv Apr 16, 2026
The adolescent brain is attuned to social and environmental exploration, allowing behavioral adaptation as experiences shape lasting patterns of morphological organization. Using a convolutional neural network on longitudinal structural MRI data, we ...
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Manifold geometry underlies a unified code for category and category-independent features

bioRxiv Apr 16, 2026
In everyday vision, animals routinely extract from the same visual stimulus both object identity and continuous identity-independent variables such as position and size. It has been shown that linear decoding performance of both kinds of information ...
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LinkLlama: Enabling Large Language Model for Chemically Reasonable Linker Design

bioRxiv Apr 16, 2026
Fragment-based drug discovery (FBDD) relies heavily on the design of chemically viable linkers to connect fragments binding to different pocket regions into potent lead molecules. While recent generative models have advanced spatial fragment linking,...
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ORION: An agentic reasoning construct for the analysis of complex human immune profiling

bioRxiv Apr 16, 2026
The capacity to generate high-dimensional biological datasets has outpaced the ability to interpret them. Technologies such as phage immunoprecipitation and sequencing (PhIP-seq) enable proteome-scale profiling of antibody repertoires, but interpreti...
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Highly Accurate Estimation of the Fold Accuracy of Protein Structural Models

bioRxiv Apr 16, 2026
The function of a protein is intrinsically linked to its three-dimensional fold, and deep learning has revolutionized the field by enabling high-accuracy structure prediction at an unprecedented scale. Nevertheless, the growing deployment of these pr...
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Strain- and age-dependent divergence in mouse appetitive spatial learning and decision strategies

bioRxiv Apr 16, 2026
Animals rely on associative spatial memory to navigate toward previously learned, reward-associated goals. This reward-guided navigation is supported by the hippocampus and its interactions with cortical and subcortical regions: processes which are v...
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Over-the-horizon extinction risk assessment reveals rapidly shifting geographic and taxonomic priorities for conservation

bioRxiv Apr 16, 2026
A central challenge in conservation is understanding how climate change interacts with other global change drivers to shape future species extinction risk, threatened species hotspots, and the effectiveness of protected areas. Here, we use an integra...
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A generative AI framework for disease-specific lung microtissue bioengineering

bioRxiv Apr 16, 2026
Generative Lung Architecture Modeling (GLAM) is an integrated bioengineering framework that couples high-resolution three-dimensional tissue imaging with generative artificial intelligence to de novo design and 3D-bioprint anatomically detailed lung ...
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TFBindFormer: A Cross-Attention Transformer for Transcription Factor-DNA Binding Prediction

bioRxiv Apr 15, 2026
Transcription factors (TFs) are central regulators of gene expression, and their selective recognition of genomic DNA underlies various biological processes. Experimental profiling of TF -- DNA interactions using chromatin immunoprecipitation followe...
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A tectal reservoir implements adaptive visuomotor transformation via serotonergically coordinated push-pull-like mechanisms

bioRxiv Apr 15, 2026
Adaptive visuomotor transformation requires sensorimotor circuits to generate accurate, robust, and flexible outputs, but its underlying cellular mechanism remains poorly understood. Leveraging a zebrafish mesoscopic connectome, we built a biological...
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