AIMC Journal:
bioRxiv

Showing 1871 to 1880 of 4956 articles

Spatial control of light-responsive proteins and optogenetics within hydrogels via volumetric bioprinting

bioRxiv Apr 13, 2026
Spatiotemporal control over cell fate and behaviour within bioprinted constructs remains a key challenge in tissue engineering. Optogenetics offers versatile potential for non-invasive regulation of biological processes. Yet, its integration within l...
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Multidomain Analysis of Clinical Cognitive Assessments and Imaging Data in Alzheimer's Disease Accurately Predicts Disease Stage and Grade Independent of Amyloid and Tau

bioRxiv Apr 13, 2026
Background Individual clinical cognitive assessments (CCA) for Alzheimer's disease (AD) provide broad disease stratification but are limited in sensitivity and specificity, requiring integration of multiple CCA for optimal disease staging. Recent wor...
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Evolutionary-scale protein language models uncover beneficial variants in a Sorghum bicolor diversity panel

bioRxiv Apr 13, 2026
Quantitative genetic approaches such as genome-wide association studies and genomic prediction are widely used to identify favourable genetic variation, but they have limited resolution due to linkage disequilibrium. Comparative genomics approaches, ...
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Encoding models uncover fine-grained feature selectivity for bodies, hands and tools

bioRxiv Apr 13, 2026
Category-selective areas in the occipitotemporal cortex (OTC) are typically characterized by broad tuning, yet neuroimaging suggests a finer-grained organization reflecting distinct computational roles. We combined image-level fMRI with artificial ne...
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CRIS: A Centralized Resource for High-Quality RNA Structure and Interaction Data in the AI Era

bioRxiv Apr 12, 2026
As interest in RNA-based therapeutics expands, there is a growing demand for RNA structure elucidation and RNA-RNA interactions in both academic and clinical settings. Despite rapid advances in methods for RNA structure determination, the field faces...
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fMRI-Based Prediction of Eye Gaze During Naturalistic Movie Viewing Reveals Eye-Movement-Related Brain Activity

bioRxiv Apr 12, 2026
Background: Eye gaze provides crucial insights into perceptual and cognitive processes during naturalistic movie viewing, yet concurrent eye tracking is often unavailable in functional MRI (fMRI) research. While deep learning models can estimate gaze...
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Pipette: Encoding scientific literature into an executable Skill Graph for multi-agent bioinformatics

bioRxiv Apr 12, 2026
The cost of genomic sequencing has fallen by several orders of magnitude, yet data analysis remains a bottleneck concentrated among researchers with specialized computational expertise. While Large Language Models can generate bioinformatics code, th...
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Cyclome: Large-scale replica-exchange dynamics of 930 cyclic peptide reveal thermal stability and critical metal-binding behavior

bioRxiv Apr 12, 2026
Cyclic peptides are recognized as versatile scaffolds for therapeutic and functional applications due to their structural stability and resistance to degradation. Despite this promise, systematic analysis and prediction of their thermal stability rem...
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HiReS: A Method for Automated Morphometric Trait Extraction from High-Resolution Plankton Images

bioRxiv Apr 12, 2026
Trait-based analyses in plankton ecology require measurements from large numbers of individuals, yet morphometric data are typically collected manually from small subsets. Although deep learning methods enable automated detection and segmentation, ex...
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Sustaining Control and Agency Under Threat: Computational Pathways to Persistence and Escape

bioRxiv Apr 12, 2026
Adaptive behavior requires deciding when to persist and when to disengage under uncertainty and partial outcome control. Avoidance has often been studied as a response to threat or cost, yet existing paradigms cannot disentangle whether disengagement...
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