AIMC Journal:
bioRxiv

Showing 2051 to 2060 of 4956 articles

Detecting and Subtyping Ketoacidosis from Metabolomic Patterns in Forensic Casework

bioRxiv Mar 12, 2026
Subtyping of ketoacidosis, a metabolic state characterized by blood acidification due to various causes, remains challenging in forensic casework. Postmortem omics samples paired with machine learning offers an independent tool to address this challe...
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Benchmarking zero-shot single-cell foundation model embeddings for cellular dynamics reconstruction

bioRxiv Mar 12, 2026
Reconstructing cellular trajectories from time-resolved single-cell transcriptomics is fundamental to understanding processes from embryonic development to cancer progression. While single-cell foundation models (scFMs) promise universal biological r...
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GCN-Mamba: Graph Convolutional Network with Mamba for Antibacterial Synergy Prediction

bioRxiv Mar 12, 2026
The escalating crisis of antimicrobial resistance necessitates novel therapeutic strategies, among which drug combination therapy shows great promise by enhancing efficacy and reducing toxicity. However, identifying effective synergistic pairs from t...
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HitAnno: Atlas-level cell type annotation based on scATAC-seq data via a hierarchical language model

bioRxiv Mar 12, 2026
The single-cell assay for transposase-accessible chromatin using sequencing (scATAC-seq) has emerged as a core technology for dissecting cellular epigenomic heterogeneity and gene regulatory programs. With the emergence of atlas-level scATAC-seq data...
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mnDINO: Accurate and robust segmentation of micronuclei with vision transformer networks

bioRxiv Mar 12, 2026
Recent advances in cell segmentation successfully produce models that generalize across various cell-lines and imaging types. However, these methods still fail to recognize subcellular structures such as micronuclei (MN), which are rare and tiny DNA-...
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Cell-type specific population codes link inferior temporal cortex to object recognition behavior

bioRxiv Mar 11, 2026
A spatially distributed population of neurons in the macaque inferior temporal (IT) cortex supports object recognition behavior, but the cell-type specificity of the population in forming behaviorally sufficient object decodes remains poorly understo...
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mRNA-Protein Coordination is Contextualized by Metastatic Biological Phenotypes

bioRxiv Mar 11, 2026
A central goal of conducting omics measurements is to understand how molecular features inform higher-order cell- and tissue-level phenotypes. In particular, multi-omics offers insights into how information encoded by the genome is coordinated throug...
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Cell-type-specific sustained value representations in the claustrum

bioRxiv Mar 11, 2026
Flexible decision-making relies on interactions between frontal cortex and subcortical structures. The claustrum, a subcortical nucleus highly interconnected with frontal cortex, influences cortical activity and has been implicated in cognitive funct...
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Distinct cellular DNA methylation mechanisms underlie common and rare genetic risk for brain disorders

bioRxiv Mar 11, 2026
Noncoding genetic variation contributes to brain disorder risk, but the mechanisms through which it acts in specific brain cell types remain unclear. DNA methylation (DNAm), a highly cell type-specific regulatory layer in the brain, may mediate nonco...
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Automated extraction and optimization of protein purification protocols using multi-agent large language models

bioRxiv Mar 11, 2026
Recent advances in Large Language Models (LLMs) present new opportunities for automating critical bottlenecks in scientific workflows such as literature reviews or protocol design. One such bottleneck is the purification of recombinant proteins, a vi...
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