AIMC Journal:
bioRxiv

Showing 2111 to 2120 of 4956 articles

GWAS Summary Statistic Tool: A Meta-Analysis and Parsing Tool for Polygenic Risk Score Calculation

bioRxiv Mar 6, 2026
Motivation: GWAS (genome-wide association study) summary statistic files are essential inputs for polygenic risk score (PRS) calculation, yet identifying suitable files across thousands of catalog entries requires downloading large files and manually...
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Discovery of a phenazine thiol conjugase from sparse data using genome-informed machine learning

bioRxiv Mar 6, 2026
Machine learning has enabled powerful biological discoveries using models trained on large datasets. However, for many important biological questions, such as identifying enzymes that transform understudied substrates, sparsity of training data is of...
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Neural microstates underlying categorical speech perception using Bayesian nonparametrics

bioRxiv Mar 6, 2026
Categorical perception (CP) reflects the human auditory system ability to map continuous acoustic signals onto discrete categories. Understanding the relationship between neural dynamics and perceptual decisions is central to speech language processi...
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Evolutionarily conserved neural dynamics across mice, monkeys, and humans

bioRxiv Mar 6, 2026
On evolutionary timescales, brain circuits adapt to support survival in each species ecological niche. While some anatomical aspects of neural circuitry are conserved across species with distant evolutionary origins, each species also exhibits specif...
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A normative reference for large-scale human brain dynamics across the lifespan

bioRxiv Mar 6, 2026
Human brain function emerges from dynamic reconfigurations of large-scale neural networks. While population-level reference charts have transformed the study of static brain structure and connectivity, an equivalent normative framework for intrinsic ...
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A Resolution-Agnostic Geometric Transformer for Chromosome Modeling Using Inertial Frame

bioRxiv Mar 5, 2026
Chromosomes are the carriers of genetic information. Further understanding their 3D structure can help reveal gene-regulatory mechanisms and cellular functions. However, high-resolution 3D structures are often missing due to the high cost and inheren...
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PAMG-AT: A Physiological Attention Multi-Graph Model with Adaptive Topology for Stress Detection using Wearable Devices

bioRxiv Mar 5, 2026
Stress detection with wearable physiological sensors is vital in digital health and affective computing. Conventional machine learning techniques usually examine physiological signals separately, missing the intricate inter-signal connections involve...
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Aβ-Overlapping Ectodomain Binding of the Clinical-Stage TREM2 Agonist VG-3927

bioRxiv Mar 5, 2026
Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial immune receptor genetically and functionally linked to Alzheimers disease (AD). VG-3927, the first clinical-stage small-molecule TREM2 agonist, has been proposed to function as ...
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Determinants of visual ambiguity resolution

bioRxiv Mar 5, 2026
Visual inputs during natural perception are highly ambiguous: objects are frequently occluded, lighting conditions vary, and object identification depends significantly on prior experiences. However, why do certain images remain unidentifiable while ...
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From Prefix to Path: Learning Temporally Consistent Biomolecular Dynamics from Limited Initial Data

bioRxiv Mar 5, 2026
Molecular dynamics (MD) simulations provide detailed insights into biomolecular motion but are often limited by the prohibitive cost of sampling long-timescale behavior. Here, we present a Transformer-based framework that reconstructs temporally cont...
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