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bioRxiv

Showing 2321 to 2330 of 4979 articles

On why and how to encode probability distributions on graph representations of omics data: enhancing predictive tasks and knowledge discovery

bioRxiv Feb 19, 2026
The growing availability and complexity of omics data have driven the development of specialized algorithms for modeling molecular systems. Although graph-based learning methods effectively represent biological interactions, they often neglect the st...
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Intragenic methylation repatterning is associated with alternative splicing and unique epigenetic phenotypes

bioRxiv Feb 19, 2026
The role of intragenic cytosine methylation in shaping phenotypes has been contentious. Recent studies show association between stress and alternative splicing of transcripts, but without functional genome-wide or single-position analysis. We utilize...
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LLM-PathwayCurator transforms enrichment terms into audit-gated decision-grade claims

bioRxiv Feb 19, 2026
Pathway enrichment of omics data requires careful interpretation, and LLM-PathwayCurator transforms enrichment outputs into auditable, evidence-linked claims with redundancy-highlighting module mapping. Across seven cohorts from The Cancer Genome Atl...
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Neural Representational Geometry of Feature Binding Operations

bioRxiv Feb 19, 2026
The brain faces the feature binding problem: how are multiple stimulus features and variables combined into coherent representations that support flexible behavior? A key finding from neuroscience is that some brain regions employ factorized represen...
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RosetteArray Platform for Quantitative High-Throughput Screening of Human Neurodevelopmental Risk

bioRxiv Feb 18, 2026
Neural organoids have revolutionized how human neurodevelopmental disorders (NDDs) are studied. Yet, their utility for screening chemical hazards and prospective therapeutics for NDDs is limited by a lack of morphological reproducibility and cost-eff...
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Reconstructing signaling histories of single cells via perturbation screens and transfer learning

bioRxiv Feb 18, 2026
Manipulating the signaling environment is an effective approach to alter cellular states for broad-ranging applications, from engineering tissues to treating diseases. Such manipulation requires knowing the signaling states and histories of the cells...
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Brain morphological pattern is associated with the presence, severity, and transition of transdiagnostic psychiatric disorders in preadolescents

bioRxiv Feb 18, 2026
Cognitive function, psychological processes, mental states, and behaviors are key dimensions of human subjective experience that separately relate to mental disorders across diagnostic categories. However, whether these dimensions are linked to commo...
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Phylogenetic estimation of diversity-dependent biogeographic rates using deep learning

bioRxiv Feb 18, 2026
Ecological theory predicts that local species richness can influence biogeographic rates of speciation, extinction, and dispersal. For instance, increasing the number of competing species within a region may cause local speciation and dispersal rates...
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Summary statistics and approximate bayesian computation are comparable to convolutional neural networks for inferring times to fixation

bioRxiv Feb 18, 2026
Detecting signatures of positive selection in genomes is a common application of population genetics and one of the most influential models for this task is the hard selective sweep where a de novo mutation rapidly fixes. Many statistics have been de...
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Insulin resistance modifies longitudinal multi-omics responses to habitual diet

bioRxiv Feb 18, 2026
How habitual diet influences the gut microbiome and plasma metabolome across insulin resistance states remains unclear. We conducted year-long multi-omics profiling of 71 deeply phenotyped adults, integrating repeated assessments of diet, metabolome,...
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